(E,1S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]hept-2-en-1-ol | 193559-65-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E,1S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]hept-2-en-1-ol
• CAS: 193559-65-8
• 化学式: C₁₉H₃₈O₄Si
• 分子量: 358.594
• InChiKey: ONSMGHIYXNLPKB-ODQHEUEKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.64
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (E,1S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]hept-2-en-1-ol 在 ruthenium trichloride 、 sodium periodate 、 四丁基氟化铵 作用下， 生成 (R)-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-methoxymethoxy-acetic acid
  参考文献：
  名称：

  Diastereoselective addition (η2-alkyne)Ti(O-i-Pr)2 complexes to 2,3-O-isopropylideneglyceraldehyde

  摘要：

  The title alkyne-titanium complexes, prepared from propargyl ethers, Ti(O-i-Pr)(4), and i-PrMgCl, reacted with 2,3-O-isopropylideneglyceraldehyde in good to excellent diastereoselectivities of up to 94:6 to afford the anti-adducts, which are useful precursor for the preparation of optically active polyhydroxy compounds. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00990-8
• 作为产物：
  描述：

  tert-butyl(hept-2-yn-1-yloxy)dimethylsilane 、 (R)-(+)-2,2-二甲基-1,3-二氧戊环-4-甲醛 在 titanium(IV) isopropylate 、 异丙基氯化镁 作用下， 以 乙醚 为溶剂， 以48%的产率得到(E,1S)-2-[[tert-butyl(dimethyl)silyl]oxymethyl]-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]hept-2-en-1-ol
  参考文献：
  名称：

  Diastereoselective addition (η2-alkyne)Ti(O-i-Pr)2 complexes to 2,3-O-isopropylideneglyceraldehyde

  摘要：

  The title alkyne-titanium complexes, prepared from propargyl ethers, Ti(O-i-Pr)(4), and i-PrMgCl, reacted with 2,3-O-isopropylideneglyceraldehyde in good to excellent diastereoselectivities of up to 94:6 to afford the anti-adducts, which are useful precursor for the preparation of optically active polyhydroxy compounds. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(97)00990-8

文献信息

• Diastereoselective addition (η2-alkyne)Ti(O-i-Pr)2 complexes to 2,3-O-isopropylideneglyceraldehyde
  作者：Koki Yamashita、Hirokazu Urabe、Fumie Sato

  DOI：10.1016/s0040-4039(97)00990-8

  日期：1997.6

  The title alkyne-titanium complexes, prepared from propargyl ethers, Ti(O-i-Pr)(4), and i-PrMgCl, reacted with 2,3-O-isopropylideneglyceraldehyde in good to excellent diastereoselectivities of up to 94:6 to afford the anti-adducts, which are useful precursor for the preparation of optically active polyhydroxy compounds. (C) 1997 Elsevier Science Ltd.