4-(2-Formamidophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoic acid | 142183-23-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(2-Formamidophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoic acid
• 英文别名: 4-(2-formamidophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoic acid
• CAS: 142183-23-1
• 化学式: C₁₆H₂₀N₂O₆
• 分子量: 336.345
• InChiKey: KRUFCMSTXZTFLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  N-叔丁氧羰基-L-色氨酸 在 18-冠醚-6 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以93.2%的产率得到4-(2-Formamidophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxobutanoic acid
  参考文献：
  名称：

  A novel tryptophan dioxygenation by superoxide

  摘要：

  The reactions of N-acyl-L-tryptophans, (1) and (2), with O2- afforded their corresponding 2,3-bond cleavage compounds, (5) and (7), as the major products. On the other hand, the reactions of N-acyl-L-tryptophan alkylamides, (3) and (4), with O2- afforded their corresponding dioxindoles, (8) and (9), as the major products. A similar reactivity difference was observed for tryptophan-containing dipeptides, (10) and (11).

  DOI：

  10.1016/s0040-4039(00)92244-5

文献信息

• A novel tryptophan dioxygenation by superoxide
  作者：Koichi Itakura、Koji Uchida、Shunro Kawakishi

  DOI：10.1016/s0040-4039(00)92244-5

  日期：1992.4

  The reactions of N-acyl-L-tryptophans, (1) and (2), with O2- afforded their corresponding 2,3-bond cleavage compounds, (5) and (7), as the major products. On the other hand, the reactions of N-acyl-L-tryptophan alkylamides, (3) and (4), with O2- afforded their corresponding dioxindoles, (8) and (9), as the major products. A similar reactivity difference was observed for tryptophan-containing dipeptides, (10) and (11).
• Itakura, Koichi; Uchida, Koji; Kawakishi, Shunro, Bioscience, Biotechnology and Biochemistry, 1994, vol. 58, # 3, p. 488 - 493
  作者：Itakura, Koichi、Uchida, Koji、Kawakishi, Shunro

  DOI：——

  日期：——