7-氟-2-氧-1,2,3,4-四氢喹啉-4-羧酸 | 923120-55-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 7-氟-2-氧-1,2,3,4-四氢喹啉-4-羧酸
• 英文名称: 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid
• 英文别名: 7-fluoro-2-oxo-3,4-dihydro-1H-quinoline-4-carboxylic acid
• CAS: 923120-55-2
• 化学式: C₁₀H₈FNO₃
• mdl: MFCD08691352
• 分子量: 209.177
• InChiKey: WQOGWVAXXVNUOX-UHFFFAOYSA-N

物化性质

• 沸点：
  423.6±45.0 °C(Predicted)
• 密度：
  1.440±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl 5-[(3-phenylpropyl)amino]pentanoate hydrochloride 、 7-氟-2-氧-1,2,3,4-四氢喹啉-4-羧酸 在 三乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 、 水 、 lithium hydroxide 作用下， 以 N,N-二甲基乙酰胺 、 1,4-二氧六环 、 甲醇 为溶剂， 反应 1.25h， 以27.2%的产率得到5-[(7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-4-carbonyl)(3-phenylpropyl)amino]pentanoic acid
  参考文献：
  名称：

  [EN] TERTIARY AMIDES AND METHOD OF USE
  [FR] AMIDES TERTIAIRES ET PROCÉDÉ D'UTILISATION

  摘要：

  公开号：

  WO2017177004A8

文献信息

• [EN] INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7<br/>[FR] DÉRIVÉS D'INDANE UTILES EN TANT QUE MODULATEURS DE MGLUR7
  申请人：TAKEDA PHARMACEUTICALS CO

  公开号：WO2018047983A1

  公开（公告）日：2018-03-15

  The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X, Y, Z, D, R1, R2, R3, R4, R12, R15nd R16 are as defined in the specification, a process for their preparation, pharmaceutical compositions containing them and their use as modulators of mGluR7.

  本发明提供了化合物的公式(I)及其药用盐，其中n、X、Y、Z、D、R1、R2、R3、R4、R12、R15和R16如规范中所定义，以及它们的制备方法、含有它们的药物组合物以及它们作为mGluR7调节剂的用途。
• TERTIARY AMIDES AND METHOD OF USE
  申请人：AbbVie Inc.

  公开号：US20190119200A1

  公开（公告）日：2019-04-25

  Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein G 1 , G 2 , G 3 , L 1 , L 2 , and L 3 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by the modulation of lysophosphatidic acid receptor 1. Methods for making the compounds are described. Also described are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.
• [EN] COMPOSITIONS AND METHODS OF TREATMENT FOR TUMORS IN THE NERVOUS SYSTEM<br/>[FR] COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DE TUMEURS DANS LE SYSTÈME NERVEUX
  申请人：UNIV GEORGETOWN

  公开号：WO2011156632A2

  公开（公告）日：2011-12-15

  The invention provides compounds, compositions and methods for preventing and treating tumors of the nervous system, by means of compounds that inhibit or modulate p75 neurotrophic receptors. Compounds of the invention have structures of the form G-H-I, wherein G is a small ring system reminiscent of redox-mediating moieties in metabolism, H is a linker of up to 8 atoms in length, and I is a simple end group such as a lower alkyl or small heteroaryl or heterocyclic ring system.