heptakis(6-deoxy-6-nonanethio-2,3-di-O-methyl)-β-cyclodextrin | 1420858-07-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: heptakis(6-deoxy-6-nonanethio-2,3-di-O-methyl)-β-cyclodextrin
• CAS: 1420858-07-6
• 化学式: C₁₁₉H₂₂₄O₂₈S₇
• 分子量: 2327.53
• InChiKey: PJNJBDRNBDCCNF-UAATUYIKSA-N

反应信息

• 作为产物：
  描述：

  heptakis (6-O-methylsulfonyl-2,3-di-O-methyl)-β-cyclodextrin 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 73.0h， 以45%的产率得到heptakis(6-deoxy-6-nonanethio-2,3-di-O-methyl)-β-cyclodextrin
  参考文献：
  名称：

  Design, synthesis, and in vitro evaluation of new amphiphilic cyclodextrin-based nanoparticles for the incorporation and controlled release of acyclovir

  摘要：

  Acyclovir possesses low solubility in water and in lipid bilayers, so that its dosage forms do not allow suitable drug levels at target sites following oral, local, or parenteral administration. In order to improve this lack of solubility, new cyclodextrin-based amphiphilic derivatives have been designed to form nanoparticles, allowing the efficient encapsulation of this hydrophobic antiviral agent. The present work first describes the synthesis and characterization of five new O-2,O-3 permethylated O-6 alkylthio- and perfluoroalkyl-propanethio-amphiphilic beta-cyclodextrins. These derivatives have been obtained with good overall yields. The capacity of these molecules to form nanoparticles in water and to encapsulate acyclovir has then been studied. The nanoparticles prepared from the new beta-cyclodextrin derivatives have been characterized by dynamic light scattering and have an average size of 120 nm for the fluorinated derivatives and 220 nm for the hydrogenated analogs. They all allowed high loading and sustained release of acyclovir. (c) 2012 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ejpb.2012.09.013