1-[2-methoxy-4-(3-methylbut-2-enyloxy)-6-[(2-trimethylsilylethoxy)methoxy]phenyl]butan-1-one | 1245818-22-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[2-methoxy-4-(3-methylbut-2-enyloxy)-6-[(2-trimethylsilylethoxy)methoxy]phenyl]butan-1-one
• 英文别名: 1-[2-Methoxy-4-(3-methylbut-2-enoxy)-6-(2-trimethylsilylethoxymethoxy)phenyl]butan-1-one；1-[2-methoxy-4-(3-methylbut-2-enoxy)-6-(2-trimethylsilylethoxymethoxy)phenyl]butan-1-one
• CAS: 1245818-22-7
• 化学式: C₂₂H₃₆O₅Si
• 分子量: 408.61
• InChiKey: RIQDGMLZRVUEEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.71
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  54
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[2-methoxy-4-(3-methylbut-2-enyloxy)-6-[(2-trimethylsilylethoxy)methoxy]phenyl]butan-1-one 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以45%的产率得到1-(2-hydroxy-6-methoxy-4-(3-methylbut-2-enyloxy)phenyl)butan-1-one
  参考文献：
  名称：

  Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

  摘要：

  We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.029
• 作为产物：
  描述：

  1-[4-hydroxy-2-methoxy-6-[(2-trimethylsilylethoxy)methoxy]phenyl]butan-1-one 、 1-溴-3-甲基-2-丁烯 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以60%的产率得到1-[2-methoxy-4-(3-methylbut-2-enyloxy)-6-[(2-trimethylsilylethoxy)methoxy]phenyl]butan-1-one
  参考文献：
  名称：

  Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds

  摘要：

  We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.06.029

文献信息

• Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds
  作者：Haruhisa Kikuchi、Shinya Ishiko、Koji Nakamura、Yuzuru Kubohara、Yoshiteru Oshima

  DOI：10.1016/j.tet.2010.06.029

  日期：2010.8

  We have studied the diversity of secondary metabolites of cellular slime molds to utilize them as new biological resources for natural product chemistry. From the methanol extract of fruiting bodies of Polysphondylium tenuissimum, we obtained five prenylated and geranylated aromatic compounds, Pt-1-5 (1-5). An additional aromatic compound, Ppc-1 (6), was isolated from Polysphondylium pseudo-candidum. The structures of these compounds were determined by spectral analysis, and synthetic routes to 4, 5, and 6 were developed. Compound 5 showed the glucose consumption-promotive activity on 3T3-L1 cells. (c) 2010 Elsevier Ltd. All rights reserved.