2-benzoyl-7-nitro-3,4-dihydro-2H-benzopyran | 1191065-07-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-benzoyl-7-nitro-3,4-dihydro-2H-benzopyran
• 英文别名: (7-nitro-3,4-dihydro-2H-chromen-2-yl)-phenylmethanone
• CAS: 1191065-07-2
• 化学式: C₁₆H₁₃NO₄
• 分子量: 283.284
• InChiKey: CBVFFZBULDTAHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  72.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(5-nitro-2-vinylphenoxy)-1-phenylethanone 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以33%的产率得到2-benzoyl-7-nitro-3,4-dihydro-2H-benzopyran
  参考文献：
  名称：

  A novel carbanion-olefin intramolecular cyclization: synthesis of substituted 2-aroyl-3,4-dihydro-2H-benzopyrans from salicylaldehydes

  摘要：

  Utilization of a novel carbanion-olefin intramolecular 6-endo-trig cyclization reaction to provide 2-aroyl-3,4-dihydro-2H-benzopyrans is described. Through a sequence of a Wittig reaction, O-alkylation, and carbanion-olefin intramolecular cyclization, salicylaldehydes were converted into a series of new 2-aroyl-3,4-dihydro-2H-benzopyrans in two steps or in one-pot reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.132

文献信息

• A novel carbanion-olefin intramolecular cyclization: synthesis of substituted 2-aroyl-3,4-dihydro-2H-benzopyrans from salicylaldehydes
  作者：Liang-Yeu Chen、Sie-Rong Li、Po-Yuan Chen、Ian-Lih Tsai、Chia-Ling Hsu、Hsin-Ping Lin、Tzu-Pin Wang、Eng-Chi Wang

  DOI：10.1016/j.tetlet.2009.07.132

  日期：2009.10

  Utilization of a novel carbanion-olefin intramolecular 6-endo-trig cyclization reaction to provide 2-aroyl-3,4-dihydro-2H-benzopyrans is described. Through a sequence of a Wittig reaction, O-alkylation, and carbanion-olefin intramolecular cyclization, salicylaldehydes were converted into a series of new 2-aroyl-3,4-dihydro-2H-benzopyrans in two steps or in one-pot reaction. (C) 2009 Elsevier Ltd. All rights reserved.