| 1400930-57-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1400930-57-5
• 化学式: C₂₁H₃₈O₃Si₂
• 分子量: 394.702
• InChiKey: NDWLEKKRMAJHID-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 zinc(II) chloride 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以86%的产率得到1-(4-((tert-butyldimethylsilyl)oxy)-2-hydroxyphenyl)propan-1-one
  参考文献：
  名称：

  Positional chemoselectivity in the Zn(II)-mediated removal of phenol protecting groups

  摘要：

  A protocol was developed for the chemoselective ortho-deprotection of polyphenolic substrates using readily available (ZnX2)-X-II salts. This procedure provides exceptional positional selectivity for the deprotection of phenols that reside adjacent to directing carbonyl functionality in the presence of similar protecting groups at the meta and para positions. Good to excellent yields of the desired free phenols were obtained (<= 96%), and a wide assortment of protecting groups was readily removed under the reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.103