3-O-dodecyl-4-O-decyl-1,2:5,6-di-O-isopropylidene-D-mannitol | 876384-58-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-dodecyl-4-O-decyl-1,2:5,6-di-O-isopropylidene-D-mannitol
• 英文别名: (4R)-4-[(1R,2R)-1-decoxy-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-dodecoxyethyl]-2,2-dimethyl-1,3-dioxolane
• CAS: 876384-58-6
• 化学式: C₃₄H₆₆O₆
• 分子量: 570.894
• InChiKey: WYOQZUGDEHOJAV-SEVDZJIVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.7
• 重原子数：
  40
• 可旋转键数：
  25
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-O-dodecyl-4-O-decyl-1,2:5,6-di-O-isopropylidene-D-mannitol 在 Amberlyst(R) 15 作用下， 以 乙醇 、 水 为溶剂， 反应 48.0h， 以157.0 mg的产率得到3-dodecyl-4-decyl-O-D-mannitol
  参考文献：
  名称：

  Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins

  摘要：

  A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cubic, hexagonal, and lamellar, as well as a separate micellar phase. These are features that have promise for the crystallization of integral membrane proteins. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.103
• 作为产物：
  描述：

  双丙酮-D-甘露糖醇 在 氢氧化钾 作用下， 以 二甲基亚砜 、 甲苯 为溶剂， 反应 48.0h， 生成 3-O-dodecyl-4-O-decyl-1,2:5,6-di-O-isopropylidene-D-mannitol
  参考文献：
  名称：

  Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins

  摘要：

  A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cubic, hexagonal, and lamellar, as well as a separate micellar phase. These are features that have promise for the crystallization of integral membrane proteins. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.11.103