(+/-)-1ξ.3ξ-dibromo-2-oxo-(4arH.8atH)-decalin | 76158-40-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (+/-)-1ξ.3ξ-dibromo-2-oxo-(4arH.8atH)-decalin
• 英文别名: (+/-)-1ξ.3ξ-dibromo-2-oxo-(4arH.8atH)-decalin；(+/-)-1ξ.3ξ-Dibrom-2-oxo-(4arH.8atH)-decalin
• CAS: 76158-40-2
• 化学式: C₁₀H₁₄Br₂O
• 分子量: 310.029
• InChiKey: VWHQHTHNTPADKE-DKATWDMPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  13.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  17.07
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2,4,6-三甲基吡啶 、 (+/-)-1ξ.3ξ-dibromo-2-oxo-(4arH.8atH)-decalin 生成 5,6,7,8-四氢-2-萘酚
  参考文献：
  名称：

  Diet and Exercise Habits of Patients with Diabetes, Dyslipidemia, Cardiovascular Disease or Hypertension

  摘要：

  Objective: The objective of this study was to determine whether free-living individuals diagnosed with diabetes, dyslipidemia, cardiovascular disease or hypertension follow standard dietary recommendations for treatment of these diet-modifiable disorders.Methods: Data are from 1,782 adult men and women who completed an annual clinic visit as part of a large study of diet and health. Usual dietary intake over the previous month was assessed with a self-administered food frequency questionnaire. Trained staff obtained a detailed medical history and information on health and exercise habits, measured height and weight, and collected a fasting blood specimen to measure total serum cholesterol, triglycerides and carotenoids. Multivariate, linear regression was used to test associations of diet-modifiable chronic diseases with diet and exercise habits.Results: 42% of the study sample reported at least one diet-modifiable disease or risk factor for disease. These individuals had higher total serum cholesterol (p < 0.001) and triglycerides p < 0.001) compared to those without these conditions. Diabetics consumed a greater percent of energy from fat (p < 0.01), and men with hypertension consumed a greater percent energy from saturated fat (p < 0.05) compared to those without these conditions. There were few other differences in dietary intake between diseased and healthy individuals. and on average, all participants had diets that were not consistent with recommended guidelines for prevention or treatment of these diet-modifiable disorders. Forty-six percent of all participants were overweight or obese, and BMI was significantly higher among participants with at least one diet-modifiable disorder (p < 0.001). Healthy and diseased participants exercised about 17 minutes per day, and compared to non-diabetics, persons with diabetes exercised with 25% less intensity (p < 0.05).Conclusion: Participants in this sample with diet-modifiable disorders reported that they are motivated to eat less fat, but most are still overweight or obese, consume a diet high in fat and low in fruits and vegetables and engage in very little physical exercise. New strategies are needed to help patients adopt and maintain healthful dietary practices that will reduce their risk.

  DOI：

  10.1080/07315724.2002.10719241
• 作为产物：
  描述：

  trans-decalin-2-one 在 氢溴酸 、 溴 、 溶剂黄146 作用下， 生成 (+/-)-1ξ.3ξ-dibromo-2-oxo-(4arH.8atH)-decalin
  参考文献：
  名称：

  Diet and Exercise Habits of Patients with Diabetes, Dyslipidemia, Cardiovascular Disease or Hypertension

  摘要：

  Objective: The objective of this study was to determine whether free-living individuals diagnosed with diabetes, dyslipidemia, cardiovascular disease or hypertension follow standard dietary recommendations for treatment of these diet-modifiable disorders.Methods: Data are from 1,782 adult men and women who completed an annual clinic visit as part of a large study of diet and health. Usual dietary intake over the previous month was assessed with a self-administered food frequency questionnaire. Trained staff obtained a detailed medical history and information on health and exercise habits, measured height and weight, and collected a fasting blood specimen to measure total serum cholesterol, triglycerides and carotenoids. Multivariate, linear regression was used to test associations of diet-modifiable chronic diseases with diet and exercise habits.Results: 42% of the study sample reported at least one diet-modifiable disease or risk factor for disease. These individuals had higher total serum cholesterol (p < 0.001) and triglycerides p < 0.001) compared to those without these conditions. Diabetics consumed a greater percent of energy from fat (p < 0.01), and men with hypertension consumed a greater percent energy from saturated fat (p < 0.05) compared to those without these conditions. There were few other differences in dietary intake between diseased and healthy individuals. and on average, all participants had diets that were not consistent with recommended guidelines for prevention or treatment of these diet-modifiable disorders. Forty-six percent of all participants were overweight or obese, and BMI was significantly higher among participants with at least one diet-modifiable disorder (p < 0.001). Healthy and diseased participants exercised about 17 minutes per day, and compared to non-diabetics, persons with diabetes exercised with 25% less intensity (p < 0.05).Conclusion: Participants in this sample with diet-modifiable disorders reported that they are motivated to eat less fat, but most are still overweight or obese, consume a diet high in fat and low in fruits and vegetables and engage in very little physical exercise. New strategies are needed to help patients adopt and maintain healthful dietary practices that will reduce their risk.

  DOI：

  10.1080/07315724.2002.10719241

文献信息

• 263. Experiments on the synthesis of santonin. Part II. The preparation of compounds containing the dienone system present in santonin
  作者：F. D. Gunstone、R. M. Heggie

  DOI：10.1039/jr9520001437

  日期：——
• Ganapathi, Journal of the Indian Chemical Society, 1938, vol. 15, p. 407
  作者：Ganapathi

  DOI：——

  日期：——
• Rao; Kuppuswamy, Journal of the Annamalai University, 1937, vol. 7, p. 22,24
  作者：Rao、Kuppuswamy

  DOI：——

  日期：——