(S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide | 347383-69-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide
• 英文别名: (2S)-2-[[(2R)-4-[(4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-1,1,1-trifluoro-4-oxobutan-2-yl]amino]-N-phenylmethoxypropanamide
• CAS: 347383-69-1
• 化学式: C₂₄H₂₆F₃N₃O₅
• 分子量: 493.483
• InChiKey: OQXPORUBBXHANA-FFZOFVMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  (S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide 在 palladium dihydroxide 2,4,6-三甲基吡啶 、 lithium hydroxide 、 N-羟基-7-氮杂苯并三氮唑 、 氢气 、 双氧水 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 四氢呋喃 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 生成 (R)-2-[(R)-4,4,4-Trifluoro-3-((S)-1-hydroxycarbamoyl-ethylamino)-butyrylamino]-propionic acid methyl ester
  参考文献：
  名称：

  10.1002/1099-0690(20022)2002:3<428::aid-ejoc428<3.0.co;2-j

  摘要：

  DOI：

  10.1002/1099-0690(20022)2002:3<428::aid-ejoc428<3.0.co;2-j
• 作为产物：
  描述：

  (4S)-benzyl-3-[(E)-4,4,4-trifluorobut-2-enoyl]-oxazolidin-2-one 、 alanine hydroxamic acid benzyl ester mono TFA salt 在 2,4,6-三甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 72.0h， 生成 (S)-2-[(S)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide 、 (S)-2-[(R)-3-((S)-4-Benzyl-2-oxo-oxazolidin-3-yl)-3-oxo-1-trifluoromethyl-propylamino]-N-benzyloxy-propionamide
  参考文献：
  名称：

  Solution/solid-phase synthesis of partially modified retro- ψ [NHCH(CF 3 )]-peptidyl hydroxamates

  摘要：

  The synthesis of a novel family of partially-modified (PM) retropeptidyl hydroxamates incorporating a [CH(CF3)CH2CO] unit as a surrogate of the conventional malonyl group, has been accomplished both in solution and in solid-phase. The key step is the Michael-type N-addition of free or polymer bound alpha -amino hydroxamates to 3-(E-enoyl)-1,3-oxazolidin-2-ones, which takes place very effectively, although with low stereocontrol. A number of tri- and tetra-peptidyl hydroxamates were obtained either in diastereomerically pure form (by solution-phase synthesist after chromatographic purification), or as mixtures of two epimers in very good chemical purity (by solid-phase, after release from the resin), demonstrating that this method is suitable for preparing combinatorial libraries of PM retro-psi [NHCH(CF3)]-peptidyl hydroxamates for screening as metalloprotease inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00375-6

文献信息

• Solution/solid-phase synthesis of partially modified retro- ψ [NHCH(CF 3 )]-peptidyl hydroxamates
  作者：Alessandro Volonterio、Pierfrancesco Bravo、Matteo Zanda

  DOI：10.1016/s0040-4039(01)00375-6

  日期：2001.4

  The synthesis of a novel family of partially-modified (PM) retropeptidyl hydroxamates incorporating a [CH(CF3)CH2CO] unit as a surrogate of the conventional malonyl group, has been accomplished both in solution and in solid-phase. The key step is the Michael-type N-addition of free or polymer bound alpha -amino hydroxamates to 3-(E-enoyl)-1,3-oxazolidin-2-ones, which takes place very effectively, although with low stereocontrol. A number of tri- and tetra-peptidyl hydroxamates were obtained either in diastereomerically pure form (by solution-phase synthesist after chromatographic purification), or as mixtures of two epimers in very good chemical purity (by solid-phase, after release from the resin), demonstrating that this method is suitable for preparing combinatorial libraries of PM retro-psi [NHCH(CF3)]-peptidyl hydroxamates for screening as metalloprotease inhibitors. (C) 2001 Elsevier Science Ltd. All rights reserved.
• 10.1002/1099-0690(20022)2002:3<428::aid-ejoc428<3.0.co;2-j
  作者：Volonterio, Alessandro、Bellosta, Stefano、Bravo, Pierfrancesco、Canavesi, Monica、Corradi, Eleonora、Meille, Stefano V.、Monetti, Mara、Moussier, Nathalie、Zanda, Matteo

  DOI：10.1002/1099-0690(20022)2002:3<428::aid-ejoc428<3.0.co;2-j

  日期：——