3α-(3-quinolinecarbonyloxy)-nortropane | 128367-71-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3α-(3-quinolinecarbonyloxy)-nortropane
• CAS: 128367-71-5
• 化学式: C₁₇H₁₈N₂O₂
• 分子量: 282.342
• InChiKey: FHSVLLCILJZHDD-FICVDOATSA-N

反应信息

• 作为产物：
  描述：

  endo-(8-methyl-8-azabicyclo<3.2.1>oct-3-yl) 3-quinolinecarboxylate 在 1-氯乙基氯甲酸酯 、 碳酸氢钠 、 甲醇 作用下， 以 氯仿 为溶剂， 反应 2.0h， 以75%的产率得到3α-(3-quinolinecarbonyloxy)-nortropane
  参考文献：
  名称：

  Synthesis of heteroaromatic tropeines and heterogeneous binding to glycine receptors

  摘要：

  Heteroaromatic carboxylic esters of (nor) tropine were synthesized. Tropine esters displaced [(3)H]strychnine binding to glycine receptors of rat spinal cord with low Hill slopes. Two-site displacement resulted in nanomolar IC(50,1) and micromolar IC(50,2) values, and IC(50,2)/IC(50,1) ratios up to 615 depending on the heteroaromatic rings and N-methyl substitution. Nortropeines displayed high affinity and low heterogeneity. IC(50,1) and IC(50,2) values of tropeines did not correlate suggesting different binding modes/sites. Glycine potentiated only the nanomolar displacement reflecting positive allosteric interactions and potentiation of ionophore function. Affinities of three (nor) tropeines were different for glycine receptors but identical for 5-HT(3) receptors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.08.029