3-ethyl-1,2-dimethyl-3,12-dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinoline | 1333397-51-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-ethyl-1,2-dimethyl-3,12-dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinoline
• 英文别名: 7-Ethyl-5,6-dimethyl-20-oxa-7,12-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1,3(11),4(8),5,9,12,14,16,18-nonaene；7-ethyl-5,6-dimethyl-20-oxa-7,12-diazapentacyclo[11.8.0.03,11.04,8.014,19]henicosa-1,3(11),4(8),5,9,12,14,16,18-nonaene
• CAS: 1333397-51-5
• 化学式: C₂₂H₂₀N₂O
• 分子量: 328.414
• InChiKey: BVHGLMUFMDLWQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-ethyl-2,3-dimethyl-1H-indol-5-amine 、 2-(2-丙炔氧基)苯甲醛 在 copper(l) iodide 作用下， 反应 2.0h， 以85%的产率得到3-ethyl-1,2-dimethyl-3,12-dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinoline
  参考文献：
  名称：

  Synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines via intramolecular aza Diels–Alder reaction

  摘要：

  An efficient and convenient one-pot intramolecular aza Diels-Alder approach for the synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines has been reported. Particularly valuable features of this methodology include simple execution, inexpensive catalyst, and good product yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.07.033

文献信息

• Synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines via intramolecular aza Diels–Alder reaction
  作者：Subburethinam Ramesh、Rajagopal Nagarajan

  DOI：10.1016/j.tetlet.2011.07.033

  日期：2011.9

  An efficient and convenient one-pot intramolecular aza Diels-Alder approach for the synthesis of dihydrochromeno[4,3-b]pyrrolo[3,2-f]quinolines has been reported. Particularly valuable features of this methodology include simple execution, inexpensive catalyst, and good product yields. (C) 2011 Elsevier Ltd. All rights reserved.