6-Ethylpyrano[3,2-c]quinoline-2,4,5-trione | 1448640-49-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-Ethylpyrano[3,2-c]quinoline-2,4,5-trione
• 英文别名: 6-ethylpyrano[3,2-c]quinoline-2,4,5-trione
• CAS: 1448640-49-0
• 化学式: C₁₄H₁₁NO₄
• 分子量: 257.246
• InChiKey: OXKPWFOFWUJDAY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-Ethylpyrano[3,2-c]quinoline-2,4,5-trione 、 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde 在 sodium acetate 、 溶剂黄146 作用下， 反应 2.0h， 以70%的产率得到3-[(6,8-dibromo-7-hydroxychromon-3-yl)methylene]-6-ethyl-6H-pyrano[3,2-c]quinoline-2,4,5-(3H,5H)-trione
  参考文献：
  名称：

  Studies on the Chemical Behavior of the Novel 6,8-Dibromo-7-hydroxychromone-3-carboxaldehyde towards Some Carbon Nucleophilic Reagents

  摘要：

  A novel 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde (4) was prepared by the Vilsemier-Haack formylation of 3,5-dibromo-2,4-dihydroxy acetophenone (3). The chemical reactivity of carboxaldehyde 4 was studied towards some carbon nucleophiles as cyclic and acyclic active methylene nucleophiles and also 1,3-C,N- and 1,3-C,C-binucleophiles as a route to achieve ring transformation to produce a variety of heterocyclic systems. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data.

  DOI：

  10.3987/com-13-12709

文献信息

• Studies on the Chemical Behavior of the Novel 6,8-Dibromo-7-hydroxychromone-3-carboxaldehyde towards Some Carbon Nucleophilic Reagents
  作者：Magdy A. Ibrahim、Tarik E. Ali、Azza M. El-Kazak、Amira M. Mohamed

  DOI：10.3987/com-13-12709

  日期：——

  A novel 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde (4) was prepared by the Vilsemier-Haack formylation of 3,5-dibromo-2,4-dihydroxy acetophenone (3). The chemical reactivity of carboxaldehyde 4 was studied towards some carbon nucleophiles as cyclic and acyclic active methylene nucleophiles and also 1,3-C,N- and 1,3-C,C-binucleophiles as a route to achieve ring transformation to produce a variety of heterocyclic systems. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data.