1-(difluoromethyl)cyclohexanol | 1538671-28-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(difluoromethyl)cyclohexanol
• 英文别名: 1-(Difluoromethyl)cyclohexan-1-ol
• CAS: 1538671-28-1
• 化学式: C₇H₁₂F₂O
• mdl: MFCD22975417
• 分子量: 150.168
• InChiKey: UEJMPWFQHMQDOV-UHFFFAOYSA-N

物化性质

• 沸点：
  180.7±15.0 °C(Predicted)
• 密度：
  1.138±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (二氟甲基)三甲基硅烷 、 环己酮 在 六甲基磷酰三胺 、 cesium fluoride 、 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 25.0h， 以60%的产率得到1-(difluoromethyl)cyclohexanol
  参考文献：
  名称：

  CHF 2 TMS / HMPA对可烯化酮的直接亲核二氟甲基化

  摘要：

  容易获得的二氟甲基化试剂Me 3 SiCF 2 H可以在温和条件下，在HMPA存在下，从多种醛和酮以高收率，以多产率合成二氟甲基醇。该添加剂使得以前可挑战的可烯丙基酮的亲核二氟甲基化成为可能。DMPU可以用作二氟甲基化反应中HMPA的无毒替代品，尽管在这种情况下收率稍低。该方法与环状，无环芳基酮配合使用，可耐受各种官能团。

  DOI：

  10.1016/j.tet.2016.01.032

文献信息

• ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR
  申请人：AbbVie Deutschland GmbH & Co. KG

  公开号：EP2970146A1

  公开（公告）日：2016-01-20
• PATTERNING PROCESS
  申请人：Hatakeyama Jun

  公开号：US20100203457A1

  公开（公告）日：2010-08-12

  A pattern is formed by coating a chemically amplified positive resist composition comprising a resin comprising acid labile group-containing recurring units and a photoacid generator onto a substrate, drying to form a resist film, exposing the resist film to high-energy radiation through a phase shift mask including a lattice-like first shifter and a second shifter arrayed on the first shifter and consisting of lines which are thicker than the line width of the first shifter, PEB, developing to form a positive pattern, illuminating or heating the positive pattern to eliminate acid labile groups for increasing alkaline solubility and to induce crosslinking for imparting solvent resistance, coating a reversal film, and dissolving away the positive pattern in an alkaline wet etchant to form a pattern by way of positive/negative reversal.
• [EN] ACYLAMINOCYCLOALKYL COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF DOPAMINE D3 RECEPTOR<br/>[FR] COMPOSÉS D'ACYLAMINOCYCLOALKYLE APPROPRIÉS POUR LE TRAITEMENT DE TROUBLES RÉPONDANT À LA MODULATION DU RÉCEPTEUR D3 DE LA DOPAMINE
  申请人：ABBVIE DEUTSCHLAND

  公开号：WO2014140246A1

  公开（公告）日：2014-09-18

  The present invention relates to novel acylaminocycloalkyl compounds, in particular to the compounds of the formula I as described herein and to their salts and N-oxides. The compounds possess valuable therapeutic properties and are suitable, in particular, for treating diseases that respond to modulation of the dopamine D3 receptor. In formula I, the variables have the following meanings: m is 1 or 2, n is 1 or 2, A is selected from the group consisting of CH2, CH2CH2, CHFCH2 and CF2CH2, R1 is an oxygen containing cyclic radical selected such as C3-C6 cycloalkyl, which carries one or two oxygen containing radicals selected from the group consisting of OH, C1-C2-alkoxy, fluorinated C1-C2-alkoxy, and a carbonyl oxygen,, R2 is selected from the group consisting of hydrogen, OH and fluorine, R3a is selected from the group consisting of hydrogen and methyl, R3b is selected from the group consisting of hydrogen and methyl, R4 is branched C4-C6 alkyl or branched fluorinated C4-C6 alkyl, and R5 is inter alia C1-C6 alkyl, fluorinated C1-C3 alkyl, C1-C2-alkoxy-C1-C4-alkyl, fluorinated C1-C2-alkoxy-C1-C4-alkyl, hydroxy-C1-C4-alkyl, fluorinated hydroxy-C1-C4-alkyl, oxetanyl, fluorinated oxetanyl, oxolanyl, fluorinated oxolanyl, C3-C5 cycloalkyl, fluorinated C3-C5 cycloalkyl, etc.