Methyl 6-[4-(4-aminophenyl)quinolin-2-yl]oxy-2,2-dimethylhexanoate | 141746-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 6-[4-(4-aminophenyl)quinolin-2-yl]oxy-2,2-dimethylhexanoate
• CAS: 141746-49-8
• 化学式: C₂₄H₂₈N₂O₃
• 分子量: 392.498
• InChiKey: FJHSWIZBEOAIBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  74.4
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 6-[4-(4-aminophenyl)quinolin-2-yl]oxy-2,2-dimethylhexanoate 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 6-<<4-(4-aminophenyl)-2-quinolyl>oxy>-2,2-dimethylhexanoic acid
  参考文献：
  名称：

  .omega.-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists

  摘要：

  A series of omega-[(4-phenyl-2-quinolyl)oxy]alkanoic acid derivatives was prepared which inhibited the binding of the leukotriene B4 to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes. A structure-activity relationship was investigated. The length of the carboxylic acid side chain was important for potent binding activity. The replacement of the oxygen atom at the beginning of the chain with other polar or nonpolar linking groups led to considerable loss of potency, indicating that the oxygen linking atom might be involved in the receptor recognition. Alpha-Substitution on the carboxylic acid side chain led to substantially more potent compounds. Substitution on the phenyl ring and on the quinoline ring was also evaluated.

  DOI：

  10.1021/jm00101a007
• 作为产物：
  描述：

  methyl 6-bromo-2,2-dimethylhexanoate 在 silver carbonate 、 tin(ll) chloride 作用下， 以 甲醇 、 甲苯 为溶剂， 反应 50.0h， 生成 Methyl 6-[4-(4-aminophenyl)quinolin-2-yl]oxy-2,2-dimethylhexanoate
  参考文献：
  名称：

  .omega.-[(4-Phenyl-2-quinolyl)oxy]alkanoic acid derivatives: a new family of potent LTB4 antagonists

  摘要：

  A series of omega-[(4-phenyl-2-quinolyl)oxy]alkanoic acid derivatives was prepared which inhibited the binding of the leukotriene B4 to its receptors on guinea pig spleen membranes and on human polymorphonuclear leukocytes. A structure-activity relationship was investigated. The length of the carboxylic acid side chain was important for potent binding activity. The replacement of the oxygen atom at the beginning of the chain with other polar or nonpolar linking groups led to considerable loss of potency, indicating that the oxygen linking atom might be involved in the receptor recognition. Alpha-Substitution on the carboxylic acid side chain led to substantially more potent compounds. Substitution on the phenyl ring and on the quinoline ring was also evaluated.

  DOI：

  10.1021/jm00101a007

文献信息

• New cysteine derivatives having expectorant activity
  申请人：MAGIS FARMACEUTICI S.P.A.

  公开号：EP0301474B1

  公开（公告）日：1993-09-29
• SUBSTITUTED BICYCLIC BIS-ARYL COMPOUNDS EXHIBITING SELECTIVE LEUKOTRIENE B 4? ANTAGONIST ACTIVITY, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS
  申请人：RHONE-POULENC RORER S.A.

  公开号：EP0540604A1

  公开（公告）日：1993-05-12
• US4910222A
  申请人：——

  公开号：US4910222A

  公开（公告）日：1990-03-20
• US5366982A
  申请人：——

  公开号：US5366982A

  公开（公告）日：1994-11-22
• US5492915A
  申请人：——

  公开号：US5492915A

  公开（公告）日：1996-02-20