5-Methyl-2-(3,4,5-trimethoxy-phenyl)-4H-pyrazolo[1,5-a]pyrimidine-7-thione | 77494-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Methyl-2-(3,4,5-trimethoxy-phenyl)-4H-pyrazolo[1,5-a]pyrimidine-7-thione
• CAS: 77494-02-1
• 化学式: C₁₆H₁₇N₃O₃S
• 分子量: 331.395
• InChiKey: MZWSQVSKRZSCSP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-5-amine 在 N,N-二甲基苯胺 、 硫脲 、 三氯氧磷 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 28.0h， 生成 5-Methyl-2-(3,4,5-trimethoxy-phenyl)-4H-pyrazolo[1,5-a]pyrimidine-7-thione
  参考文献：
  名称：

  Synthesis and antischistosomal activity of certain pyrazolo[1,5-a]pyrimidines

  摘要：

  Several 7-hydroxypyrazolo[1,5-a]pyrimidines (1-21), 7-mercaptopyrazolo[1,5-a]pyrimidines (37-49), and 4-alkylpyrazolo[1,5-a]pyrimidin-7-ones (50-55) and the corresponding 4-alkylpyrazolo[1,5-a]pyrimidine-7-thiones (56-60) were synthesized and tested for antischistosomal activity against Schistosoma mansoni. Of the compounds examined, the greatest degree of activity in vitro was found with the 7-mercaptopyrazolo[1,5-a]pyrimidines. In particular, compounds 37 and 47 proved lethal at 100 micrograms/mL after an exposure of only 1 h. The 7-hydroxypyrazolo[1,5-a]-pyrimidines were not as active. None of the compounds exhibiting in vitro activity were active against S. mansoni in vivo.

  DOI：

  10.1021/jm00137a023