H-Asp(t-Bu)-Pro-Arg(Pbf)-Gly-OH | 862408-53-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Asp(t-Bu)-Pro-Arg(Pbf)-Gly-OH
• CAS: 862408-53-5
• 化学式: C₃₄H₅₃N₇O₁₀S
• 分子量: 751.902
• InChiKey: UPRMVYHSPOCSLX-HJOGWXRNSA-N

反应信息

• 作为反应物：
  描述：

  H-Asp(t-Bu)-Pro-Arg(Pbf)-Gly-OH 在 2,4,6-三甲基吡啶 、 1-羟基苯并三唑 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以9 mg的产率得到
  参考文献：
  名称：

  RGD mounted on an L-proline scaffold

  摘要：

  The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.029
• 作为产物：
  描述：

  Fmoc-甘氨酸 、 Fmoc-L-脯氨酸 、 Fmoc-L-天冬氨酸 beta-叔丁酯 、 Fmoc-Pbf-L-精氨酸 生成 H-Asp(t-Bu)-Pro-Arg(Pbf)-Gly-OH
  参考文献：
  名称：

  RGD mounted on an L-proline scaffold

  摘要：

  The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.029