4-(5-苯基-1,3-恶唑-2-基)苯甲酸 | 108783-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-(5-苯基-1,3-恶唑-2-基)苯甲酸
• 英文名称: 4-(5-phenyloxazole-2-yl)benzoic acid
• 英文别名: 2-(4-Carboxyphenyl)-5-phenyloxazole；2-(p-carboxyphenyl)-5-phenyloxazole；4-(5-phenyl-oxazol-2-yl)-benzoic acid；4-<5-Phenyl-oxazol-2-yl>-benzoesaeure；Benzoic acid, 4-(5-phenyl-2-oxazolyl)-；4-(5-phenyl-1,3-oxazol-2-yl)benzoic acid
• CAS: 108783-73-9
• 化学式: C₁₆H₁₁NO₃
• 分子量: 265.268
• InChiKey: PGOGNGOHXADTHK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(5-苯基-1,3-恶唑-2-基)苯甲酸 在 ammonium hydroxide 、 氯化亚砜 作用下， 以 苯 为溶剂， 反应 2.0h， 生成 2-(4-Carbamidophenyl)-5-phenyloxazole
  参考文献：
  名称：

  4-（5-芳基恶唑基-2）苯甲酸及其衍生物的合成，光谱和发光性质

  摘要：

  DOI：

  10.1007/bf00478139
• 作为产物：
  描述：

  4-氯甲酰基苯甲酸甲酯 在 sodium hydroxide 、 硫酸 、 sodium carbonate 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 6.0h， 生成 4-(5-苯基-1,3-恶唑-2-基)苯甲酸
  参考文献：
  名称：

  4-（5-芳基恶唑基-2）苯甲酸及其衍生物的合成，光谱和发光性质

  摘要：

  DOI：

  10.1007/bf00478139

文献信息

• An Efficient Two-Step Synthesis of 2,5-Disubstituted Oxazole Derivatives Involving Cu-Promoted Carbon-Carbon Single Bond Formation
  作者：Jyotirmay Maiti、Suman Biswas、Ranjan Das

  DOI：10.14233/ajchem.2016.19743

  日期：——

  Environment sensitive fluorescence probe to detect various organelles is emerging as an excellent tool to attract the attention of a large number of researchers around the globe. The recent developments have shown that oxazole dyes are very competent and can exhibit a useful fluorescence property in this direction. An efficient synthetic procedure towards 2,5-diaryl substituted oxazole derivatives have been reported. It is a two-step technique involving classical van Leusen protocol followed by copper-mediated coupling with aryl halides to introduce the required carbon-carbon single bond. The aryl groups are chosen in such a way so that the aryl functionalities at 2- and 5-positions of oxazole can act as acceptor and donor moiety respectively. Thus, in turn, the extended conjugation from donor moiety to acceptor moiety via the oxazole ring is set up therein. The oxazole derivatives were characterized by various spectroscopic measurements like NMR, IR and MS.

  环境敏感荧光探针用于检测各种细胞器，正成为吸引全球众多研究者关注的优秀工具。最近的发展表明，噁唑染料非常有效，并且在这方面可以展示出有用的荧光特性。已经报道了一种高效的合成途径用于制备2,5-二芳基取代的噁唑衍生物。这是一种两步技术，涉及经典的范·吕森法（van Leusen protocol），随后与芳基卤化物进行铜介导的耦合，以引入所需的碳-碳单键。芳基的选择方式使得噁唑在2位和5位的芳基官能团分别可以作为受体和供体部分。因此，供体部分通过噁唑环与受体部分之间建立了扩展共轭关系。噁唑衍生物通过各种光谱测量（如NMR、IR和MS）进行了表征。
• Preparation and spectra of para-substituted 2,5-diphenyloxazoles
  作者：A.T. Balaban、L. Bîrlǎdeanu、I. Bally、P.T. Frangopol、M. Mocanu、Z. Simon

  DOI：10.1016/0040-4020(63)85035-8

  日期：1963.1

  acid azlactone with halobenzenes, toluene, and anisole, followed by treatment with phosphorus oxychloride. Grignard and Ullmann reactions of p-halo-substituted 2,5-diaryloxazoles are described. Absorption spectra of these compounds are discussed and the pronounced bathochromic effect of coupled donor and acceptor groups in both para positions is accounted for by a simple MO treatment.

  通过对位取代的马来酸氮杂内酯与苯的弗里德-克来福特反应，或在对位上被卤素，甲基，甲氧基或硝基取代的2,5-二芳基恶唑，在对位上被卤素，甲基，甲氧基或硝基取代。将马来酸，内酯与卤代苯，甲苯和苯甲醚，然后用三氯氧化磷处理。描述了对卤取代的2，5-二芳基恶唑的Grignard和Ullmann反应。讨论了这些化合物的吸收光谱，并通过简单的MO处理说明了两个对位上耦合的供体和受体基团的显着红移效应。
• Compounds for Nonsense Suppression, and Methods for Their Use
  申请人：Almstead Neil G.

  公开号：US20090253699A1

  公开（公告）日：2009-10-08

  The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.

  本发明涉及使用本发明的化合物或组合物治疗或预防与mRNA中无意义突变相关的疾病的方法、化合物和组合物。更具体地，本发明涉及用于抑制与mRNA中无意义突变相关的早期翻译终止的方法、化合物和组合物。
• METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH
  申请人：Almstead Neil G.

  公开号：US20110046136A1

  公开（公告）日：2011-02-24

  The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of functional proteins encoded by nucleic acid sequences comprising a nonsense mutation and the use of such proteins for prevention, management and/or treatment of diseases associated with a nonsense mutation(s) in a gene.

  本发明涉及由核酸序列编码的功能性蛋白质，其中包括一个无意义突变。本发明还涉及用于生产由包含无意义突变的核酸序列编码的功能性蛋白质的方法，以及利用这些蛋白质预防、管理和/或治疗与基因中的无意义突变相关的疾病。
• KRASOVITSKIJ, B. M.;VOLKOV, V. L.;SHERSHUKOV, V. M.;VEREZUBOVA, S. A., SB. NAUCH. TR. VNII MONOKRISTALLOV, STSINTILLYATSION. MATERIALOV I OSOBO +
  作者：KRASOVITSKIJ, B. M.、VOLKOV, V. L.、SHERSHUKOV, V. M.、VEREZUBOVA, S. A.

  DOI：——

  日期：——