5-methyl-2-phenyl-quinolin-4-ol | 116690-09-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-methyl-2-phenyl-quinolin-4-ol
• 英文别名: 5-Methyl-2-phenyl-chinolin-4-ol；5-methyl-2-phenyl-1H-quinolin-4-one
• CAS: 116690-09-6
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: OAPRIBVYNXEJHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-methyl-2-phenyl-quinolin-4-ol 在 三氯氧磷 作用下， 生成 4-chloro-5-methyl-2-phenyl-quinoline
  参考文献：
  名称：

  Bangdiwala; Desai, Journal of the Indian Chemical Society, 1954, vol. 31, p. 43,46

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-双(3-甲基苯基)硫脲 在 氢氧化钾 、 乙醇 作用下， 生成 5-methyl-2-phenyl-quinolin-4-ol
  参考文献：
  名称：

  Frontal lobe dysfunction in amyotrophic lateral sclerosis

  摘要：

  The aim of the present study was to investigate the involvement of frontal lobe dysfunction in amyotrophic lateral sclerosis (ALS) using ocular motor paradigms and neuropsychological testing. Fifty-one patients with ALS participated in the following ocular motor tasks: (1) a three-choice task and (2) a remembered saccade task. The patients underwent a clinical and neuropsychological evaluation. One-third of ALS patients presented with signs of frontal dysfunction, as determined by their high distractibility factors (DF) in the three-choice task and their performances in both the Wisconsin and Stroop tests. ALS patients exhibited longer latencies to eye movement than controls in the performance of the remembered saccade task, specifically in performance of both remembered and delayed saccades, but saccade accuracy was not impaired. Finally, performance indices of the ocular motor tasks, in particular the DF, was correlated only with the degree of dysarthria. (C) 2002 Elsevier Science B.V. All rights reserved.

  DOI：

  10.1016/s0022-510x(01)00683-9

文献信息

• NAIK, V. A.;MEHTA, A. G.;DESAI, B. M., J. INST. CHEM. (INDIA), 59,(1987) N 5, 209-210
  作者：NAIK, V. A.、MEHTA, A. G.、DESAI, B. M.

  DOI：——

  日期：——