3,4-Dihydroxy-1-(4-methylphenyl)butan-1-one | 1083095-12-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3,4-Dihydroxy-1-(4-methylphenyl)butan-1-one
• CAS: 1083095-12-8
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: NCQMTXOUWWQWAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (3-(p-tolyl)-4,5-dihydroisoxazol-5-yl)methanol 在 水 、 铁粉 、 氯化铵 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 2-(4-甲基苯基)呋喃 、 3,4-Dihydroxy-1-(4-methylphenyl)butan-1-one
  参考文献：
  名称：

  Reduction of Δ²-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent

  摘要：

  A detailed study of a procedure for the selective reduction of Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of beta-hydroxy ketones, including the conjugated beta-hydroxy ketones.

  DOI：

  10.1021/jo801831c

文献信息

• Reduction of Δ²-Isoxazolines to β-Hydroxy Ketones with Iron and Ammonium Chloride as Reducing Agent
  作者：Dahong Jiang、Yuanwei Chen

  DOI：10.1021/jo801831c

  日期：2008.11.21

  A detailed study of a procedure for the selective reduction of Delta(2)-isoxazolines to the corresponding beta-hydroxy ketones is reported. The use of iron and ammonium chloride as the reducing agent in the presence of water results in a facile and chemoselective protocol for the preparation of beta-hydroxy ketones, including the conjugated beta-hydroxy ketones.