Acetic acid (1R,2R,3S,4R,5R)-2-[(2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-4-methoxy-5-(4-methoxy-phenoxy)-tetrahydro-pyran-2-yloxy]-3-methoxy-6,8-dioxa-bicyclo[3.2.1]oct-4-yl ester | 226069-58-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Acetic acid (1R,2R,3S,4R,5R)-2-[(2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-4-methoxy-5-(4-methoxy-phenoxy)-tetrahydro-pyran-2-yloxy]-3-methoxy-6,8-dioxa-bicyclo[3.2.1]oct-4-yl ester
• CAS: 226069-58-5
• 化学式: C₂₇H₃₆O₁₄
• 分子量: 584.574
• InChiKey: BOGIWNUJNGIBOD-DVCSACCXSA-N

反应信息

• 作为反应物：
  描述：

  Acetic acid (1R,2R,3S,4R,5R)-2-[(2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-4-methoxy-5-(4-methoxy-phenoxy)-tetrahydro-pyran-2-yloxy]-3-methoxy-6,8-dioxa-bicyclo[3.2.1]oct-4-yl ester 在 potassium carbonate 、 苄胺 、 三氟乙酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 21.5h， 生成 Acetic acid (2R,3R,4S,5R,6R)-5-[(2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-4-methoxy-5-(4-methoxy-phenoxy)-tetrahydro-pyran-2-yloxy]-6-acetoxymethyl-4-methoxy-2-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-3-yl ester
  参考文献：
  名称：

  Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

  摘要：

  A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00156-0
• 作为产物：
  描述：

  Acetic acid (2R,3R,4S,5R)-5-benzyloxy-4-methoxy-3-(4-methoxy-phenoxy)-6-(2,2,2-trichloro-acetimidoyloxy)-tetrahydro-pyran-2-ylmethyl ester 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 三乙胺 作用下， 以 二氯甲烷 、 叔丁醇 为溶剂， 反应 17.5h， 生成 Acetic acid (1R,2R,3S,4R,5R)-2-[(2R,3R,4S,5R,6R)-3-acetoxy-6-acetoxymethyl-4-methoxy-5-(4-methoxy-phenoxy)-tetrahydro-pyran-2-yloxy]-3-methoxy-6,8-dioxa-bicyclo[3.2.1]oct-4-yl ester
  参考文献：
  名称：

  Synthetic oligosaccharides having various functional domains: Potent and potentially safe heparin mimetics

  摘要：

  A synthetic heptadecasaccharide, comprising an antithrombin III binding domain, a thrombin binding domain, and a neutral methylated hexasaccharide sequence, was obtained through a convergent synthesis. This compound displayed in vitro anticoagulant properties similar to that of standard heparin but, in contrast with heparin, escaped neutralization by platelet factor 4, a protein released by activated platelets. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00156-0