methyl 2,3,4-tri-o-acetyl-6-deoxy-6-[3,4-(methylenedioxy)-phenyl]-β-D-glucopyranoside | 862499-10-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2,3,4-tri-o-acetyl-6-deoxy-6-[3,4-(methylenedioxy)-phenyl]-β-D-glucopyranoside
• 英文别名: [(2R,3R,4S,5R,6R)-4,5-diacetyloxy-2-(1,3-benzodioxol-5-ylmethyl)-6-methoxyoxan-3-yl] acetate
• CAS: 862499-10-3
• 化学式: C₂₀H₂₄O₁₀
• 分子量: 424.405
• InChiKey: BQVNKLCCDITXLG-OUUBHVDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  bis(benzo[d][1,3]dioxol-5-yl)zinc 、 methyl 2,3,4-tri-O-acetyl-6-deoxy-6-iodo-β-D-glucopyranoside 在 iron(III) chloride 四甲基乙二胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以90%的产率得到methyl 2,3,4-tri-o-acetyl-6-deoxy-6-[3,4-(methylenedioxy)-phenyl]-β-D-glucopyranoside
  参考文献：
  名称：

  EP1724248

  摘要：

  公开号：

文献信息

• Process for production of aromatic compounds
  申请人：Nakamura Masaharu

  公开号：US20070123734A1

  公开（公告）日：2007-05-31

  A problem of the present invention is to provide an economical process with minimized toxicity for producing an aromatic compound having a variety of substituents such as various alkyl groups, and the problem is solved by a process for production of an aromatic compound represented by formula (1) below, which comprises reacting a compound represented by formula (2) below with an aromatic magnesium reagent represented by formula (3a) below in the presence of an iron catalyst and a diamine compound: wherein R is an optionally substituted hydrocarbon group or a C 3 -C 10 saturated or unsaturated ring group; A is an optionally substituted C 4 -C 20 aromatic group or an optionally substituted heteroaromatic group; X is a halogen atom or a sulfonic acid ester; and Y 1 is bromine, iodine, chlorine or a carbanion ligand.

  本发明的问题是提供一种经济的过程，最小化毒性，用于生产具有各种取代基（例如各种烷基）的芳香化合物，该问题通过以下公式（1）所代表的芳香化合物的生产过程得到解决，其中，在铁催化剂和二胺化合物的存在下，将以下公式（2）所代表的化合物与以下公式（3a）所代表的芳香基镁试剂反应：其中，R是可选的取代的碳氢化合物基团或C3-C10饱和或不饱和环基团；A是可选的取代的C4-C20芳香基团或可选的取代的杂环芳基团；X是卤素原子或磺酸酯；Y1是溴、碘、氯或碳阴离子配体。
• PROCESS FOR PRODUCTION OF AROMATIC COMPOUNDS
  申请人：Japan Science and Technology Agency

  公开号：EP1724248A1

  公开（公告）日：2006-11-22

  A problem of the present invention is to provide an economical process with minimized toxicity for producing an aromatic compound having a variety of substituents such as various alkyl groups, and the problem is solved by a process for production of an aromatic compound represented by formula (1) below, which comprises reacting a compound represented by formula (2) below with an aromatic magnesium reagent represented by formula (3a) below in the presence of an iron catalyst and a diamine compound: wherein R is an optionally substituted hydrocarbon group or a C3 - C10 saturated or unsaturated ring group; A is an optionally substituted C4 - C20 aromatic group or an optionally substituted heteroaromatic group; X is a halogen atom or a sulfonic acid ester; and Y1 is bromine, iodine, chlorine or a carbanion ligand.

  本发明的一个问题是为生产具有各种取代基（如各种烷基）的芳香族化合物提供一种经济的、毒性最小的工艺，该问题是通过一种生产下式（1）所代表的芳香族化合物的工艺来解决的，该工艺包括在铁催化剂和二胺化合物存在下，使下式（2）所代表的化合物与下式（3a）所代表的芳香族镁试剂反应： 其中 R 是任选取代的烃基或 C3 - C10 饱和或不饱和环基；A 是任选取代的 C4 - C20 芳香族基团或任选取代的杂芳香族基团；X 是卤素原子或磺酸酯；Y1 是溴、碘、氯或碳阴离子配位体。
• US7781599B2
  申请人：——

  公开号：US7781599B2

  公开（公告）日：2010-08-24