tert-butyl N-[N-(9-fluorenylmethoxycarbonyl)-2-aminoethyl]-N-[5-[3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl]uracil-N¹-yl]-acetylglycinate | 1434143-44-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: tert-butyl N-[N-(9-fluorenylmethoxycarbonyl)-2-aminoethyl]-N-[5-[3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl]uracil-N¹-yl]-acetylglycinate
• 英文别名: tert-butyl 2-[[2-[2,4-dioxo-5-[4,4,4-trifluoro-3,3-bis(trifluoromethyl)but-1-ynyl]pyrimidin-1-yl]acetyl]-[2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]amino]acetate
• CAS: 1434143-44-8
• 化学式: C₃₅H₃₁F₉N₄O₇
• 分子量: 790.639
• InChiKey: YBIFBGZPVOUNJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  55
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  134
• 氢给体数：
  2
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[N-(9-fluorenylmethoxycarbonyl)-2-aminoethyl]-N-[5-[3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl]uracil-N¹-yl]-acetylglycinate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以100%的产率得到N-[N-(9-fluorenylmethoxycarbonyl)-2-aminoethyl]-N-[5-[3,3-bis-(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl]uracil-N¹-yl]acetyl glycinate
  参考文献：
  名称：

  Synthesis of Fluorine-Labeled Peptide Nucleic Acid Building Blocks as Sensors for the ¹⁹F NMR Spectroscopic Detection of Different Hybridization Modes

  摘要：

  Peptide nucleic acid (PNA) building blocks, bearing a fluorine sensor at C-5 of the uracil base [viz. trifluoromethyl and 3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl], were synthesized and incorporated to a PNA strand, and their applicability for the monitoring of different hybridization modes by F-19 NMR spectroscopy was studied. Both sensors gave unique F-19 resonance shifts in NMR when the PNA was targeted to a complementary antiparallel DNA, antiparallel RNA, parallel DNA, and parallel RNA. The 5-trifluoromethyl-derived sensor was additionally applied for the monitoring of interconversions from a parallel DNA/PNA complex to an antiparallel RNA/PNA complex and from a PNA/PNA complex to two DNA/PNA complexes (i.e., double-duplex invasion).

  DOI：

  10.1021/jo400014y
• 作为产物：
  描述：

  tert-butyl [N3-(4-methoxybenzyl)-5-iodoracil-N¹-yl]acetate 在 copper(l) iodide 、 四(三苯基膦)钯 、 ammonium cerium (IV) nitrate 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 N,N-二异丙基乙胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.0h， 生成 tert-butyl N-[N-(9-fluorenylmethoxycarbonyl)-2-aminoethyl]-N-[5-[3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl]uracil-N¹-yl]-acetylglycinate
  参考文献：
  名称：

  Synthesis of Fluorine-Labeled Peptide Nucleic Acid Building Blocks as Sensors for the ¹⁹F NMR Spectroscopic Detection of Different Hybridization Modes

  摘要：

  Peptide nucleic acid (PNA) building blocks, bearing a fluorine sensor at C-5 of the uracil base [viz. trifluoromethyl and 3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl], were synthesized and incorporated to a PNA strand, and their applicability for the monitoring of different hybridization modes by F-19 NMR spectroscopy was studied. Both sensors gave unique F-19 resonance shifts in NMR when the PNA was targeted to a complementary antiparallel DNA, antiparallel RNA, parallel DNA, and parallel RNA. The 5-trifluoromethyl-derived sensor was additionally applied for the monitoring of interconversions from a parallel DNA/PNA complex to an antiparallel RNA/PNA complex and from a PNA/PNA complex to two DNA/PNA complexes (i.e., double-duplex invasion).

  DOI：

  10.1021/jo400014y

文献信息

• Synthesis of Fluorine-Labeled Peptide Nucleic Acid Building Blocks as Sensors for the ¹⁹F NMR Spectroscopic Detection of Different Hybridization Modes
  作者：Anu Kiviniemi、Merita Murtola、Petri Ingman、Pasi Virta

  DOI：10.1021/jo400014y

  日期：2013.6.7

  Peptide nucleic acid (PNA) building blocks, bearing a fluorine sensor at C-5 of the uracil base [viz. trifluoromethyl and 3,3-bis(trifluoromethyl)-4,4,4-trifluorobut-1-ynyl], were synthesized and incorporated to a PNA strand, and their applicability for the monitoring of different hybridization modes by F-19 NMR spectroscopy was studied. Both sensors gave unique F-19 resonance shifts in NMR when the PNA was targeted to a complementary antiparallel DNA, antiparallel RNA, parallel DNA, and parallel RNA. The 5-trifluoromethyl-derived sensor was additionally applied for the monitoring of interconversions from a parallel DNA/PNA complex to an antiparallel RNA/PNA complex and from a PNA/PNA complex to two DNA/PNA complexes (i.e., double-duplex invasion).