(6S,7S)-7-(1-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7yl)-6,7-methano-3-methyl-octa-2E,4E-dienoic acid ethyl ester | 263550-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (6S,7S)-7-(1-Acetyl-4,4-dimethyl-1,2,3,4-tetrahydroquinolin-7yl)-6,7-methano-3-methyl-octa-2E,4E-dienoic acid ethyl ester
• 英文别名: ethyl (2E,4E)-5-[(1S,2S)-2-(1-acetyl-4,4-dimethyl-2,3-dihydroquinolin-7-yl)-2-methylcyclopropyl]-3-methylpenta-2,4-dienoate
• CAS: 263550-75-0
• 化学式: C₂₅H₃₃NO₃
• 分子量: 395.542
• InChiKey: RNWMZKVKWPXCCI-RLVPNRRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Tetrahydroquinoline derivatives having selective activity for retinoid x receptors
  申请人：Allergan, Inc.

  公开号：EP1354878A2

  公开（公告）日：2003-10-22

  The present invention relates to novel compounds having retinoid-like biological activity. More specifically, the present invention relates to compounds that include a substituted tetrahydroquinoline moiety and a 2,4-pentadienoic acid moiety and have selective activity for retinoid X (RXR) receptors.

  本发明涉及具有类视黄醇生物活性的新型化合物。更具体地说，本发明涉及的化合物包括一个取代的四氢喹啉分子和一个 2,4-戊二烯酸分子，对视黄醇 X（RXR）受体具有选择性活性。
• TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS
  申请人：Allergan, Inc.

  公开号：EP1117648B1

  公开（公告）日：2003-08-06
• US6048873A
  申请人：——

  公开号：US6048873A

  公开（公告）日：2000-04-11
• [EN] TETRAHYDROQUINOLINE DERIVATIVES HAVING SELECTIVE ACTIVITY FOR RETINOID X RECEPTORS<br/>[FR] DERIVES DE TETRAHYDROQUINOLINE DOTES D'UNE ACTIVITE SELECTIVE POUR LES RECEPTEURS DE RETINOIDE X
  申请人：ALLERGAN SALES INC

  公开号：WO2000020397A1

  公开（公告）日：2000-04-13

  Compounds of Formula (1), where Y is a bivalent radical having Formula (2) or Formula (3) where o is an integer from 1 to 4, where the remaining symbols have the meaning described in the specification are selective agonists of RXR retinoid receptors.