(E,E)-6-(4,5-dimethyl-1,3-dithiol-2-ylidene)hexa-2,4-dienal | 208394-23-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E,E)-6-(4,5-dimethyl-1,3-dithiol-2-ylidene)hexa-2,4-dienal
• 英文别名: (2E,4E)-6-(4,5-dimethyl-1,3-dithiol-2-ylidene)hexa-2,4-dienal
• CAS: 208394-23-4
• 化学式: C₁₁H₁₂OS₂
• 分子量: 224.348
• InChiKey: XYIHMYVVOOHAPQ-GGWOSOGESA-N

物化性质

• 沸点：
  345.0±42.0 °C(Predicted)
• 密度：
  1.214±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  67.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (E,E)-6-(4,5-dimethyl-1,3-dithiol-2-ylidene)hexa-2,4-dienal 在 哌啶 、 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 ethyl N-[(3Z,5E)-1,1,3-tricyano-7-(4,5-dimethyl-1,3-dithiol-2-ylidene)hepta-1,3,5-trien-2-yl]carbamate
  参考文献：
  名称：

  丙二腈二聚物衍生的花菁的合成，表征和光学性质

  摘要：

  丙二腈二聚体与1,3-二硫醇衍生的多元烯之间的反应提供了在新形成的CC键周围具有（Z）几何形状的推挽系统。在一种情况下，发生了花菁链的意外缩短。这些推挽导数具有微弱的交替结构和适度的光学非线性，可以通过氨基官能团进行修饰。

  DOI：

  10.1016/j.tetlet.2007.07.048
• 作为产物：
  描述：

  2,4,5-Trimethyl-1,3-dithiol-1-ium;tetrafluoroborate 、 N,N-二甲基氨基-2,4-戊二烯-5-醛 在 乙酸酐 、 sodium hydroxide 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以55%的产率得到(E,E)-6-(4,5-dimethyl-1,3-dithiol-2-ylidene)hexa-2,4-dienal
  参考文献：
  名称：

  Iminium Salts of ω-Dithiafulvenylpolyenals: An Easy Entry to the Corresponding Aldehydes and Doubly Proaromatic Nonlinear Optic-phores

  摘要：

  A short, high-yielding route to omega-dithiafulvenylpolyenals (1) via the corresponding iminium salts (2) and starting from trimethyl-1,3-dithiolium tetrafluoroborate is reported. The Knoevenagel reactions of either I or 2 with isoxazolone-containing acceptors afford merocyanines 7 and 9, in a process that is often accompanied by a vinylene-shortening side reaction. Experimental and theoretical studies reveal that compounds 7 and 9, featuring two proaromatic end groups, are strongly polarized and show good second-order nonlinear optical responses.

  DOI：

  10.1021/jo800801q

文献信息

• Fluorene acceptors with intramolecular charge-transfer from 1,3-dithiole donor moieties: novel electron transport materials
  作者：Igor F. Perepichka、Dmitrii F. Perepichka、Anatolii F. Popov、Igor F. Perepichka、Martin R. Bryce、Leonid M. Goldenberg、Antony Chesney、Adrian J. Moore、Judith A. K. Howard、Lyudmila G. Kuz’mina、Nikolai I. Sokolov

  DOI：10.1039/a800912k

  日期：——

  The synthesis, solution redox behaviour and intramolecular charge transfer properties of novel D(CH–CH)nA compounds (n = 0, 1, 3; D and A are 1,3-dithiole and nitrofluorene moieties, respectively) are reported.

  报道了新型D(CH–CH)nA化合物（n = 0, 1, 3；D和A分别为1,3-二噻烷和硝基芴基部分）的合成、溶液氧化还原行为及分子内电荷转移特性。
• Synthesis, Structure, and Optical Properties of 1,4-Dithiafulvene-Based Nonlinear Optic-phores
  作者：Silvia Alías、Raquel Andreu、María Jesús Blesa、Santiago Franco、Javier Garín、Aurora Gragera、Jesús Orduna、Pilar Romero、Belén Villacampa、Magali Allain

  DOI：10.1021/jo070694v

  日期：2007.8.1

  conformational features, ground state polarization, and linear and nonlinear optical properties have been determined experimentally and theoretically, and the results are compared to those of tetrathiafulvalene-related derivatives. The newly prepared compounds show close to optimal bond length alternation values for maximizing the first molecular hyperpolarizability, and one of them displays the highest

  合成了具有芳香性1,4-二硫富烯电子供体和很少探索的1,1,3-三氰基-2-苯基丙烯受体的多烯非线性光学（NLO）-团。通过实验和理论确定了它们的构型和构象特征，基态极化以及线性和非线性光学性质，并将结果与​​四硫富瓦烯相关衍生物进行了比较。新制备的化合物表现出接近最优键长交替的值最大化所述第一分子超极化，并且它们中的一个显示最高μβ 0曾报道为基于dithiafulvene-NLO-phore值。还报道了二硫代富烯基亚甲基转移反应的第一个实例。
• New 1,3-dithiol-2-ylidene donor–π–acceptor chromophores with intramolecular charge-transfer properties, and related donor–π–donor molecules: synthesis, electrochemistry, X-ray crystal structures, non-linear optical properties and theoretical calculations
  作者：Adrian J. Moore、Martin R. Bryce、Andrei S. Batsanov、Andrew Green、Judith A. K. Howard、Anthony Mckervey、Peter Mcguigan、Isabelle Ledoux、Enrique Ortí、Rafael Viruela、Pedro M. Viruela、Brian Tarbit

  DOI：10.1039/a708078f

  日期：——

  New donor-pi-acceptor chromophores 5a-c, 7a-c, 8a-c, 13a-c and 14b-c have been synthesised: substituted 1,3-dithiole derivatives span a range of donor abilities [viz. 4,5-dimethyl > 4,5-bis(methylsulfanyl) > 4,5-bis(methoxycarbonyl)], a conjugated ethylenic or oligoethylenic linker varies the central pi-electron unit tone, two and four conjugated double bonds) and dicyanomethylene and N-cyanoimine groups are the acceptor units. Extended tetrathiafulvalene derivatives 15a-c have also been synthesised. The electronic absorption spectra of compounds 5, 7, 8 and 14 reveal a broad low-energy intramolecular charge-transfer band [lambda(max)(MeCN) 354-533 nm] which shifts bathochromically with increasing donor strength of the dithiole ring, and with increasing length of the conjugative pathway. The solution redox properties of 5, 7, 8 and 14, studied by cyclic voltammetry, reveal a reversible one-electron oxidation wave, attributed to the formation of the radical cation of the 1,3-dithiol-2-ylidene moiety, and an irreversible one-electron reduction to form the radical anion located on the dicyanomethylene or N-cyanoimine groups. For the bis(dithiole) donors 15a-c a single two-electron redox wave is observed. The non-linear optical (NLO) properties of 7a-c and 14b have been determined using the EFISH technique: moderate NLO properties are observed for compounds 7a-c [mu.beta(0) 85-112 x 10(-48) esu] whereas for the more extensively conjugated compound 14b, the value is increased to mu.beta(0) 1170 x 10(-48) esu. The molecular structure and electronic properties of the unsubstituted (R = H) compounds 7, 8, 1 8 and 15 have been calculated within the density functional theory approach. The minimum energy conformation corresponds to the trans orientation of the side chain for 7, and the cis orientation for 8, in agreement with X-ray crystal structures and solution NMR data. The redox properties and electronic spectra are discussed on the basis of molecular orbital energies and topologies. The X-ray crystal structures of compounds 7b, 8b and 15b are reported. In 7b the 1,3-dithiol-2-ylidene and dicyanopropene systems are planar and form an angle of 3 degrees between each other; the 'butadiene' unit has a trans configuration. Molecule 8b is planar (with the exception of the methyl groups) and the imine nitrogen atom is in a syn orientation towards the dithiole group, forming a short intramolecular S ... N contact [2.719(6) Angstrom]. For both 7b and 8b pi-delocalisation is observed within the central conjugated spacer unit. Molecule 15b has a predominantly planar structure, with the central tetraene unit in an all-trans configuration.
• Highly polarized dithiafulvenes: synthesis and nonlinear optical properties
  作者：Raquel Andreu、Jorge Aramburo、Miguel Angel Cerdán、Javier Garín、Jesús Orduna、Belén Villacampa

  DOI：10.1016/j.tetlet.2005.11.112

  日期：2006.1

  Push-pull dithiafulvenes with reduced bond length alternation (BLA) and high optical nonlinearities have been prepared. The interplay between the proarornaticity of the donor and the structural and optical properties of these merocyanines is discussed. The donor ability of dithiafulvenes can reach that of ferrocene or dialkylamillophenyl groups. (c) 2005 Elsevier Ltd. All rights reserved.
• Novel NLO-phores with Proaromatic Donor and Acceptor Groups
  作者：Raquel Andreu、Javier Garín、Jesús Orduna、Rafael Alcalá、Belén Villacampa

  DOI：10.1021/ol0352005

  日期：2003.8.1

  Novel D-pi-A NLO-phores based on the 1,3-dithiol-2-ylidene donor and the thiobarbituric acceptor moieties have been prepared. Modification of the length and rigidity of the pi-spacer allows the first systematic study of the second-order nonlinear optical properties of doubly proaromatic merocyanines. The pi-electron donor efficiency of the 1,3-dithiol-2-ylidene group is superior to that of the tetrathiafulvalenyl group.