6-(1-Methylindol-4-yl)oxyquinoline | 1057257-51-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(1-Methylindol-4-yl)oxyquinoline
• CAS: 1057257-51-8
• 化学式: C₁₈H₁₄N₂O
• 分子量: 274.322
• InChiKey: BEOPAHKOBXOKGI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  27
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-(1-Methylindol-4-yl)oxyquinoline 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 反应 1.0h， 生成 1-Methyl-4-quinolin-6-yloxyindole-3-carbaldehyde
  参考文献：
  名称：

  3-Acrylamide-4-aryloxyindoles: Synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists

  摘要：

  A series of potent and selective EP3 receptor antagonists are described. Utilizing a pharmacophore model developed for the EP3 receptor, a series of 3,4-disubstituted indoles were found to be efficient ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors. An optimized molecule 7c featured a sound pro. le and potency in the functional rat and human platelet aggregation assays. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.112
• 作为产物：
  描述：

  4-溴-1-甲基吲哚 、 6-羟基喹啉 在 copper(l) iodide 、 N,N-二甲基甘氨酸盐酸盐 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 生成 6-(1-Methylindol-4-yl)oxyquinoline
  参考文献：
  名称：

  3-Acrylamide-4-aryloxyindoles: Synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists

  摘要：

  A series of potent and selective EP3 receptor antagonists are described. Utilizing a pharmacophore model developed for the EP3 receptor, a series of 3,4-disubstituted indoles were found to be efficient ligands for this target. These compounds showed high selectivity over IP, FP and other EP receptors. An optimized molecule 7c featured a sound pro. le and potency in the functional rat and human platelet aggregation assays. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.112

文献信息

• Sulfonamide peri-substituted bicyclics for occlusive artery disease
  申请人：Singh Jasbir

  公开号：US20060079520A1

  公开（公告）日：2006-04-13

  Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula A representative example is:

  酰基磺酰胺，带有周取代的融合双环环化合物，用于治疗或预防前列腺素介导的疾病或症状。这些化合物的一般公式为 代表性示例是：
• SULFONAMIDE PERT-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
  申请人：Decode Genetics

  公开号：EP1812388A1

  公开（公告）日：2007-08-01
• SULFONAMIDE PERI-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE
  申请人：DECODE GENETICS, EHF

  公开号：EP1812388B1

  公开（公告）日：2011-02-23
• US7598397B2
  申请人：——

  公开号：US7598397B2

  公开（公告）日：2009-10-06
• [EN] SULFONAMIDE PERT-SUBSTITUTED BICYCLICS FOR OCCLUSIVE ARTERY DISEASE<br/>[FR] BICYCLIQUES PERI-SUBSTITUES DE SULFONAMIDE POUR MALADIE D'ARTERE OCCLUSE
  申请人：DECODE GENETICS

  公开号：WO2006044000A1

  公开（公告）日：2006-04-27

  [EN] Acyl sulfonamide, peri-substituted, fused bicyclic ring compounds useful for the treatment or prophylaxis of a prostaglandin-mediated disease or condition are disclosed. The compounds are of the general formula (I). A representative example is formula (II):
  [FR] L'invention concerne des composés d'anneau bicyclique fusionné, péri-substitué, d'acylsulfonamide, utilisés dans le traitement ou la prophylaxie d'une maladie ou d'un trouble à médiation de prostaglandine. Les composés présentent la formule générale (I). Un exemple représentatif en est la formule (II):