4-dimethylamino-5-methylsalicylaldehyde | 58186-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-dimethylamino-5-methylsalicylaldehyde
• 英文别名: 4-(Dimethylamino)-2-hydroxy-5-methylbenzaldehyde
• CAS: 58186-70-2
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: CMFPTTXFNONIRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-dimethylamino-5-methylsalicylaldehyde 在 水 、 potassium carbonate 、 lithium hydroxide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 20.0h， 生成 6-(dimethylamino)-5-methyl-1-benzofuran-2-carboxylic acid
  参考文献：
  名称：

  [EN] ACYL SULFONAMIDES FOR TREATING CANCER
  [FR] ACYLSULFONAMIDES POUR LE TRAITEMENT DU CANCER

  摘要：

  本发明提供了一般式(I)的酰基磺酰胺化合物：其中X、R1、R2、R3、R4、R5、R6、Ra和Rb如本文所述和定义的那样，制备所述化合物的方法，用于制备所述化合物的有用中间体化合物，包含所述化合物的药物组合物和组合物，以及利用所述化合物制造用于治疗或预防疾病的药物组合物，特别是治疗或预防过度增殖性疾病的药物组合物，作为唯一药剂或与其他活性成分结合使用，以及治疗和/或预防疾病的方法，特别是癌症，更特别是KAT6A和/或KAT6B在局部扩增的癌症，所述方法包括向需要的受试者施用至少一种式(I)化合物的有效量。

  公开号：

  WO2020216701A1
• 作为产物：
  描述：

  5-dimethylamino-2-(1,3-diphenyl-imidazolidin-2-yl)-4-methyl-phenol 在 盐酸 、 水 作用下， 反应 2.0h， 以54%的产率得到4-dimethylamino-5-methylsalicylaldehyde
  参考文献：
  名称：

  N-(2,4-DIFORMYL-5-HYDROXYPHENYL)ACETAMIDE

  摘要：

  DOI：

  10.15227/orgsyn.060.0049

文献信息

• NEAR INFRARED FLUOROGEN AND FLUORESCENT ACTIVATING PROTEINS FOR IN VIVO IMAGING AND LIVE-CELL BIOSENSING
  申请人：Carnegie Mellon University

  公开号：US20140243509A1

  公开（公告）日：2014-08-28

  Tissue slices and whole organisms offer substantial challenges to fluorescence imaging. Autofluorescence and absorption via intrinsic chromophores, such as flavins, melanin, and hemoglobins, confound and degrade output from all fluorescent tags. An “optical window,” farther red than most autofluorescence sources and in a region of low hemoglobin and water absorbance, lies between 650 and 900 nm. This valley of relative optical clarity is an attractive target for fluorescence-based studies within tissues, intact organs, and living organisms. Novel fluorescent tags were developed herein, based upon a genetically targeted fluorogen activating protein and cognate fluorogenic dye that yields emission with a peak at 733 nm exclusively when complexed as a “fluoromodule”. This tool improves substantially over previously described far-red/NIR fluorescent proteins in terms of brightness, wavelength, and flexibility by leveraging the flexibility of synthetic chemistry to produce novel chromophores.

  组织切片和整个生物体对荧光成像提出了重大挑战。自发荧光和内在色素（如黄酮，黑色素和血红蛋白）的吸收会干扰和降解所有荧光标记的输出。在650到900纳米之间，比大多数自发荧光源更远的“光学窗口”处于低血红蛋白和水吸收区域内，是组织，完整器官和活体内荧光研究的有吸引力的目标。本文开发了一种新型荧光标记，基于基因定向荧光原活化蛋白和相应的荧光原染料，仅当复合为“荧光模块”时，才产生峰值为733纳米的发射。通过利用合成化学的灵活性来生产新的色素，该工具在亮度，波长和灵活性方面显着优于先前描述的远红外/近红外荧光蛋白。
• ACYL SULFONAMIDES FOR TREATING CANCER
  申请人：Bayer Aktiengesellschaft

  公开号：US20220226279A1

  公开（公告）日：2022-07-21

  The present invention provides acyl sulfonamide compounds of general formula (I): in which X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6′ R a and R b are as described and defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients as well as methods of treating and/or prophylaxing diseases, particularly cancer, more particularly cancer in which KAT6A and/or KAT6B is focally amplified, said method comprising administering an effective amount of at least one compound of formula (I) to a subject in need thereof.
• US3985763A
  申请人：——

  公开号：US3985763A

  公开（公告）日：1976-10-12
• US9023998B2
  申请人：——

  公开号：US9023998B2

  公开（公告）日：2015-05-05