(4-Methoxymethyl-cyclohexyl)-methanol | 110928-47-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (4-Methoxymethyl-cyclohexyl)-methanol
• CAS: 110928-47-7
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: KSIFEWSPJQDERU-KYZUINATSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.43
• 重原子数：
  11.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (4-Methoxymethyl-cyclohexyl)-methanol 在 溴 、 magnesium 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Solladie, Guy; Zimmermann, Richard; Bartsch, Richard, Synthesis, 1985, # 6/7, p. 662 - 665

  摘要：

  DOI：
• 作为产物：
  描述：

  TRANS-1,4-CYCLOHEXANEDIMETHANOL 、 碘甲烷 在 potassium hydride 作用下， 以44%的产率得到(4-Methoxymethyl-cyclohexyl)-methanol
  参考文献：
  名称：

  Solladie, Guy; Zimmermann, Richard; Bartsch, Richard, Synthesis, 1985, # 6/7, p. 662 - 665

  摘要：

  DOI：

文献信息

• Biocatalytic synthesis of strained carbocycles
  申请人：California Institute of Technology

  公开号：US10829792B2

  公开（公告）日：2020-11-10

  Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.

  本文提供了生产含有受约束碳环（如环丙烯分子和/或双环丁烷分子）的产品的方法。这些方法包括在血红素蛋白（如细胞色素 P450）存在下，在足以形成受约束碳环的条件下，将炔烃和碳烯前体结合。此外，还描述了用于生产受约束碳环的反应混合物，以及包含血红素蛋白及其变体的全细胞催化剂，用于形成环丙烯、双环丁烷和相关产品。
• Biocatalytic Synthesis of Strained Carbocycles
  申请人：California Institute of Technology

  公开号：US20180305721A1

  公开（公告）日：2018-10-25

  Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.
• [EN] BIOCATALYTIC SYNTHESIS OF STRAINED CARBOCYCLES<br/>[FR] SYNTHÈSE BIOCATALYTIQUE DE CARBOCYCLES CONTRAINTS
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2018175628A1

  公开（公告）日：2018-09-27

  Provided herein are methods for producing products containing strained carbocycles, such as cyclopropene moieties and/or bicyclobutane moieties. The methods include combining an alkyne and a carbene precursor in the presence of a heme protein, e.g., a cytochrome P450, under conditions sufficient to form the strained carbocycle. Reaction mixtures for producing strained carbocycles are also described, as well as whole-cell catalysts comprising heme proteins and variants thereof for forming cyclopropenes, bicyclobutanes, and related products.