1-(2-chloro-phenyl)-4-[4-(4-[1,2,4]triazol-1-ylmethyl-phenoxy)-butyl]-piperazine | 1198205-14-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(2-chloro-phenyl)-4-[4-(4-[1,2,4]triazol-1-ylmethyl-phenoxy)-butyl]-piperazine
• 英文别名: 1-(2-Chlorophenyl)-4-[4-[4-(1,2,4-triazol-1-ylmethyl)phenoxy]butyl]piperazine
• CAS: 1198205-14-9
• 化学式: C₂₃H₂₈ClN₅O
• 分子量: 425.961
• InChiKey: MZWCBYUFZCBDRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  46.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF
  申请人：Kim Yonggil

  公开号：US20090298831A1

  公开（公告）日：2009-12-03

  The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, a process for preparing the same, and in particular, a high binding for Serotonin 1A(5-hydroxytryptamine; 5-HT1A) receptor, a pharmaceutical composition for treatment and/or prevention of depression and anxiety including an effective amount of the piperazine compound, and a method of treating depression, anxiety and other conditions related to 5-HT1A receptor in a mammal.

  本发明涉及新型哌嗪衍生物或其药学上可接受的盐，其制备方法，特别是对5-羟色胺1A（5-HT1A）受体具有高结合力，包括有效量的哌嗪化合物的治疗和/或预防抑郁和焦虑的药物组合物，以及在哺乳动物中治疗抑郁症、焦虑和其他与5-HT1A受体有关的疾病的方法。
• PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF
  申请人：SK Holdings Co., Ltd.

  公开号：EP2279179A2

  公开（公告）日：2011-02-02
• US7985752B2
  申请人：——

  公开号：US7985752B2

  公开（公告）日：2011-07-26
• US8772299B2
  申请人：——

  公开号：US8772299B2

  公开（公告）日：2014-07-08
• [EN] PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME, AND USE THEREOF<br/>[FR] COMPOSÉS DE PHÉNYL-PIPÉRAZINE, COMPOSITION PHARMACEUTIQUE LES COMPRENANT, ET UTILISATION ASSOCIÉE
  申请人：SK HOLDINGS CO LTD

  公开号：WO2009145591A2

  公开（公告）日：2009-12-03

  The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, and a pharmaceutical composition for treatment and/or prevention of depression and anxiety including an effective amount of the piperazine compound.