(S)-1-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy]phenoxy-phosphoryl}pyrrolidine-2-carboxylic acid methyl ester | 1064684-35-0

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: (S)-1-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-ylmethoxy]phenoxy-phosphoryl}pyrrolidine-2-carboxylic acid methyl ester
• 英文别名: methyl (2S)-1-[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]pyrrolidine-2-carboxylate
• CAS: 1064684-35-0
• 化学式: C₂₂H₂₇FN₃O₉P
• 分子量: 527.443
• InChiKey: DHWPNTXNFNHSFE-IJDMJUJQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  144
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS
  申请人：SOFIA MICHAEL JOSEPH

  公开号：US20100016251A1

  公开（公告）日：2010-01-21

  Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

  本文披露了用于治疗哺乳动物病毒感染的核苷类衍生物的磷酰胺酯前药，该前药是一种化合物，其立体异构体、盐（酸性或碱性加合盐）、水合物、溶剂合物或结晶形式，由以下结构表示：同时还披露了治疗方法、用途和制备过程，每种方法均利用由式I表示的化合物。
• Nucleoside phosphoramidate prodrugs
  申请人：Gilead Pharmasset LLC

  公开号：EP2801580A1

  公开（公告）日：2014-11-12

  Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound or its stereoisomer, represented by the following structure: Also disclosed are uses and processes for preparing the compound represented by formula I.

  本文公开了用于治疗哺乳动物病毒感染的核苷衍生物磷酰胺原药，它是由以下结构表示的化合物或其立体异构体： 还公开了制备式 I 所表示的化合物的用途和工艺。
• US8334270B2
  申请人：——

  公开号：US8334270B2

  公开（公告）日：2012-12-18
• [EN] NUCLEOSIDE PHOSPHORAMIDATE PRODRUGS<br/>[FR] PROMÉDICAMENTS DE PHOSPHORAMIDATE DE NUCLÉOSIDE
  申请人：PHARMASSET INC

  公开号：WO2008121634A2

  公开（公告）日：2008-10-09

  [EN] Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula (I).
  [FR] L'invention concerne des promédicaments de phosphoramidate de dérivés de nucléoside pour le traitement d'infections virales chez les mammifères, qui sont un composé, son stéréo-isomère, un sel (sel d'addition acide ou basique), un hydrate, un solvate, ou une forme cristalline de celui-ci, représentés par la structure suivante : l'invention concerne également des procédés de traitement, des utilisations et des processus de préparation utilisant chacun le composé représenté par la formule (I).