(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-{{1-oxo-5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentyl}amino}hexanoic acid | 1182715-90-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-{{1-oxo-5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentyl}amino}hexanoic acid
• 英文别名: N²[(9H-fluoren-9-ylmethoxy)carbonyl]-N⁶{1-oxo-5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentyl}-L-lysine；(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-6-[5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentanoylamino]hexanoic acid
• CAS: 1182715-90-7
• 化学式: C₅₀H₄₆N₄O₅
• 分子量: 782.939
• InChiKey: XUGODGDYVMFHEK-GWHBCOKCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.7
• 重原子数：
  59
• 可旋转键数：
  17
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  131
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  、 FMOC-赖氨酸 以 N,N-二甲基甲酰胺 为溶剂， 反应 15.0h， 生成 (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-{{1-oxo-5-[4-(7-phenyl-1,10-phenanthrolin-4-yl)phenyl]pentyl}amino}hexanoic acid
  参考文献：
  名称：

  用（Baphenphenanthroline）钌（II）配合物有效标记肽的替代固相策略

  摘要：

  Abstractmagnified imageTo increase the flexibility for the insertion of highly sensitive and robust [RuII(bathophenanthroline)] complexes into peptides, we have evaluated three different solid‐phase strategies (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). Among these, insertion of the Ru‐complex‐modified lysine building block 9 turned out to be the method of choice (Scheme 5).

  DOI：

  10.1002/hlca.200800409

文献信息

• Alternative Solid-Phase Strategies for the Efficient Labelling of Peptides with (Bathophenanthroline)ruthenium(II) Complexes
  作者：Rolf A. Kramer、Willi Bannwarth

  DOI：10.1002/hlca.200800409

  日期：2009.6

  Abstractmagnified imageTo increase the flexibility for the insertion of highly sensitive and robust [RuII(bathophenanthroline)] complexes into peptides, we have evaluated three different solid‐phase strategies (bathophenanthroline=4,7‐diphenyl‐1,10‐phenanthroline). Among these, insertion of the Ru‐complex‐modified lysine building block 9 turned out to be the method of choice (Scheme 5).