N-Acetyl-3-benzoyl-4-piperidone | 144507-37-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-Acetyl-3-benzoyl-4-piperidone
• 英文别名: 1-acetyl-3-benzoylpiperidin-4-one
• CAS: 144507-37-9
• 化学式: C₁₄H₁₅NO₃
• 分子量: 245.278
• InChiKey: AISSYTWDDSDJOR-UHFFFAOYSA-N

物化性质

• 沸点：
  390.6±37.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  54.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Acetyl-3-benzoyl-4-piperidone 在 盐酸 、 聚合甲醛 、 sodium hydride 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 10.5h， 生成 5-methyl-3-phenyl-1-propan-2-yl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine
  参考文献：
  名称：

  Synthesis, in vitro [3H]prazosin displacement, and in vivo activity of 3-aryl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines, a new class of antihypertensive agents

  摘要：

  A series of new 3-aryl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines was synthesized and screened for in vitro [3H]prazosin displacement activity. The results correlated well with their antihypertensive activity in spontaneous hypertensive rats. 1-Benzyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyrid ine (50, L 16052) was selected for further pharmacological evaluations of its potency when administered orally to conscious renal hypertensive dogs.

  DOI：

  10.1021/jm00145a015
• 作为产物：
  描述：

  N-乙酰基-4-哌啶酮 在 盐酸 、 对甲苯磺酸 、 三乙胺 作用下， 以 二氯甲烷 、 苯 为溶剂， 反应 12.5h， 生成 N-Acetyl-3-benzoyl-4-piperidone
  参考文献：
  名称：

  Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents

  摘要：

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.

  DOI：

  10.1016/0223-5234(92)90085-f

文献信息

• Substituted thiazolylaminotetrahydropyridopyrimidines derivatives useful
  申请人：Ortho Pharmaceutical Corporation

  公开号：US05405848A1

  公开（公告）日：1995-04-11

  This invention relates to substituted thiazolylaminotetrahydropyridopyrimidines derivatives of the following general formula, the substituent groups of which are as defined in the specification herein: ##STR1## These compounds are useful as inhibitors of platelet aggregation and inhibitors of adhesion molecules and may be provided in pharmaceutical compositions and in methods of treating reperfusion thrombosis injury in patients.

  本发明涉及以下一般式的取代噻唑基氨基四氢吡啶嘧啶衍生物，其取代基团如本规范中所定义：##STR1## 这些化合物可用作血小板聚集抑制剂和粘附分子抑制剂，并可在治疗患者的再灌注血栓形成损伤的方法和制药组合物中提供。
• US5405848A
  申请人：——

  公开号：US5405848A

  公开（公告）日：1995-04-11
• Novel tetrahydropyrido[4,3-d]pyrimidines as gastric antilesion agents
  作者：PJ Sanfilippo、M Urbanski、L Williams、JB Press、LB Katz、DA Shriver、JA Fernandez、D Shatynski、SJ Offord

  DOI：10.1016/0223-5234(92)90085-f

  日期：1992.10

  A variety of substituted tetrahydropyrido[4,3-d]pyrimidines was prepared and found to possess gastric antilesion against ethanol-induced lesions in rats. The more potent compounds possessed similar activity against aspirin-induced gastric lesions. A selective group of compounds was determined to be inactive as gastric antisecretory agents in rabbit isolated parietal cells. The antilesion properties of these tetrahydropyrido[4,3-d]pyrimidines make them a potential alternative to prostaglandin therapy for gastric antilesion therapy and may have clinical utility in peptic ulcer disease.
• Synthesis, in vitro [3H]prazosin displacement, and in vivo activity of 3-aryl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines, a new class of antihypertensive agents
  作者：Giorgio Winters、Alberto Sala、Domenico Barone、Emiliana Baldoli

  DOI：10.1021/jm00145a015

  日期：1985.7

  A series of new 3-aryl-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridines was synthesized and screened for in vitro [3H]prazosin displacement activity. The results correlated well with their antihypertensive activity in spontaneous hypertensive rats. 1-Benzyl-3-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyrid ine (50, L 16052) was selected for further pharmacological evaluations of its potency when administered orally to conscious renal hypertensive dogs.