9-(β-D-xylofuranosyl)-N⁶-cyclopentyladenine | 161084-89-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 9-(β-D-xylofuranosyl)-N⁶-cyclopentyladenine
• 英文别名: (2R,3R,4R,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
• CAS: 161084-89-5
• 化学式: C₁₅H₂₁N₅O₄
• 分子量: 335.363
• InChiKey: SQMWSBKSHWARHU-JDTTZNEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  9-(β-D-xylofuranosyl)-N⁶-cyclopentyladenine 在 4,4'-二氨基二苯乙烯-2,2'-二磺酸 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 22.0h， 生成 2',5'-di-O-trityl-3'-fluoro-3'-deoxy-N⁶-cyclopentyladenosine
  参考文献：
  名称：

  Synthesis of 3′-Fluoro-3′-deoxy-N⁶-cyclopentyladenosine

  摘要：

  Starting from 9-(beta-D-xylofuranosyl)-6-chloropurine, the title compound was prepared in four steps. Reaction with cyclopentylamine followed by treatment of the 2'-O,5'-O-ditritylated material with diethylaminosulfur trifluoride (DAST), yielded after deprotection the desired compound.

  DOI：

  10.1080/15257779408010677
• 作为产物：
  描述：

  1-O-acetyl-2,3,5-tri-O-benzoyl-D-xylofuranose 在 三甲基氯硅烷 、 三氟甲磺酸三甲基硅酯 、 氨 、 三乙胺 、 六甲基二硅氮烷 作用下， 以 甲醇 、 乙醇 、 乙腈 为溶剂， 反应 10.5h， 生成 9-(β-D-xylofuranosyl)-N⁶-cyclopentyladenine
  参考文献：
  名称：

  Synthesis of 3′-Fluoro-3′-deoxy-N⁶-cyclopentyladenosine

  摘要：

  Starting from 9-(beta-D-xylofuranosyl)-6-chloropurine, the title compound was prepared in four steps. Reaction with cyclopentylamine followed by treatment of the 2'-O,5'-O-ditritylated material with diethylaminosulfur trifluoride (DAST), yielded after deprotection the desired compound.

  DOI：

  10.1080/15257779408010677

文献信息

• Method of increasing satellite cell proliferation with an HDAC inhibitor
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US10660902B2

  公开（公告）日：2020-05-26

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.

  本发明提供了诱导、增强或增加卫星细胞增殖的方法，以及用于筛选诱导、增强或增加卫星细胞增殖的候选化合物的检测方法。本发明还提供了修复或再生受试者受损肌肉组织的方法。
• SMALL MOLECULE SCREENING FOR MOUSE SATELLITE CELL PROLIFERATION
  申请人：PRESIDENT AND FELLOWS OF HARVARD COLLEGE

  公开号：US20180153902A1

  公开（公告）日：2018-06-07

  The invention provides methods for inducing, enhancing or increasing satellite cell proliferation, and an assay for screening for a candidate compound for inducing, enhancing or increasing satellite cell proliferation. Also provided are methods for repairing or regenerating a damaged muscle tissue of a subject.