dimethyl (2,3:4,5-di-O-isopropylidene)galactarate | 813450-69-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethyl (2,3:4,5-di-O-isopropylidene)galactarate
• 英文别名: methyl (4R,5S)-5-[(4R,5S)-5-(methoxycarbonyl)-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylate；(4R,4'S,5S,5'R)-dimethyl 2,2,2',2'-tetramethyl-[4,4'-bi(1,3-dioxolane)]-5,5'-dicarboxylate；methyl (4R,5S)-5-[(4R,5S)-5-methoxycarbonyl-2,2-dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyl-1,3-dioxolane-4-carboxylate
• CAS: 813450-69-0
• 化学式: C₁₄H₂₂O₈
• 分子量: 318.324
• InChiKey: ZTUVBUBNNIOGIC-FIRGSJFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  dimethyl (2,3:4,5-di-O-isopropylidene)galactarate 在 sodium methylate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 46.0h， 生成 N-(2-aminoethyl)-N'-dodecyl (2,3:4,5-di-O-isopropylidene)galactaric acid diamide
  参考文献：
  名称：

  Synthesis of a biotinated amphiphile

  摘要：

  The synthesis of a biotinated amphiphile assembled from D-(+)-biotin, ethylene diamine as spacer, galactaric acid and 1-dodecylamine was achieved in six steps. The key step was the synthesis of a bisacetonide protected galactaric ester, the structure of which was determined by X-ray analysis. Aminolysis, spacer attachment, coupling with biotin and deprotection led to the amphiphilic galactaramide. (C) 2004 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2004.09.063
• 作为产物：
  描述：

  meso-galactaric acid 在 硫酸 、 左旋樟脑磺酸 作用下， 以 丙酮 为溶剂， 反应 133.0h， 生成 dimethyl (2,3:4,5-di-O-isopropylidene)galactarate
  参考文献：
  名称：

  [EN] COMPOUNDS USEFUL FOR TREATING GASTROINTESTINAL TRACT DISORDERS
  [FR] COMPOSÉS UTILES POUR LE TRAITEMENT DE TROUBLES DU TRACTUS DIGESTIF

  摘要：

  本公开涉及化合物和治疗与液体潴留或盐过多有关的疾病的方法，例如心力衰竭（特别是充血性心力衰竭）、慢性肾病、晚期肾病、肝病和过氧化物酶体增殖物激活受体（PPAR）γ激动剂诱导的液体潴留。本公开还涉及化合物和治疗高血压的方法。本公开还涉及化合物和治疗胃肠道疾病的方法，包括治疗或减轻与胃肠道疾病相关的疼痛。

  公开号：

  WO2018129552A1

文献信息

• Amphetamine Prodrugs
  申请人：Shire AG

  公开号：US20140073589A1

  公开（公告）日：2014-03-13

  The present invention relates to amphetamine prodrugs which provide colonic release of amphetamine.

  本发明涉及一种安非他命前药，其提供安非他命的结肠释放。
• Compounds useful for treating gastrointestinal tract disorders
  申请人：Ardelyx, Inc.

  公开号：US11242337B2

  公开（公告）日：2022-02-08

  The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders.

  本公开内容涉及用于治疗与体液潴留或盐负荷过重相关的疾病的化合物和方法，如心力衰竭（尤其是充血性心力衰竭）、慢性肾病、终末期肾病、肝病和过氧化物酶体增殖激活受体（PPAR）γ激动剂诱导的体液潴留。本公开还涉及治疗高血压的化合物和方法。本公开还涉及治疗胃肠道疾病的化合物和方法，包括治疗或减轻与胃肠道疾病相关的疼痛。
• VERFAHREN ZUR HERSTELLUNG VON POLYMEREN TRÄGERMATERIALIEN AUF BASIS VON KOHLENHYDRAT-BIS- (METH)ACRYLAMIDEN
  申请人：Technische Universität Wien

  公开号：EP1761592A1

  公开（公告）日：2007-03-14
• Methods for the Production of Polymer Carrier Materials Based on Carbon Hydrate-Bis(Meth)Acryl-Amides
  申请人：Verdianz Thomas

  公开号：US20080300383A1

  公开（公告）日：2008-12-04

  The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.
• US7674839B2
  申请人：——

  公开号：US7674839B2

  公开（公告）日：2010-03-09