6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline | 31576-77-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline
• 英文别名: 2-Piperidino-4-phenyl-6-chlor-chinolin；6-chloro-4-phenyl-2-piperidin-1-ylquinoline
• CAS: 31576-77-9
• 化学式: C₂₀H₁₉ClN₂
• 分子量: 322.837
• InChiKey: OVECYULGNYIKMN-UHFFFAOYSA-N

物化性质

• 熔点：
  136-139 °C(Solv: hexane (110-54-3); ethyl ether (60-29-7))
• 沸点：
  508.0±50.0 °C(Predicted)
• 密度：
  1.212±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-(2-苯甲酰基-4-氯苯基)甲酰胺 在 正丁基锂 、 三乙胺 、 三氯氧磷 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.25h， 生成 6-chloro-4-phenyl-2-(piperidin-1-yl)quinoline
  参考文献：
  名称：

  A convenient synthesis of quinolines by reactions of o-isocyano-β-methoxystyrenes with nucleophiles

  摘要：

  2,4-Disubstituted quinolines have been synthesized by reactions of o-isocyano-beta-methoxystyrenes, which can be easily prepared from commercially available o-aminophenyl ketones in three steps, with alkyl(or aryl)lithiums in generally good yields. Subsequently, oisocyano-beta-methoxystyrenes have also proved to react efficiently with lithium dialkylamides to afford the corresponding 4-substituted N,Ndialkylquinolin-2-amines in satisfactory yields. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.09.069

文献信息

• [EN] NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS MODULATEURS DU MÉTABOLISME CELLULAIRE ET LEURS UTILISATIONS
  申请人：CRESCENTA BIOSCIENCES

  公开号：WO2021150645A1

  公开（公告）日：2021-07-29

  A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.

  一类化合物，能够结合到脂肪酸结合蛋白（FABP4）并调节脂肪细胞代谢以促进增强葡萄糖利用，以及包含该类化合物的药物组合物，与药用辅料或载体相结合，并可选地进一步与治疗活性剂相结合，以及这些化合物在医学上的应用和用于制备治疗作用于FABP4的疾病的药物。
• [EN] NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF FOR THE TREATMENT OF VIRAL DISEASES<br/>[FR] NOUVEAUX COMPOSÉS MODULANT LE MÉTABOLISME CELLULAIRE ET LEURS UTILISATIONS POUR LE TRAITEMENT DE MALADIES VIRALES
  申请人：CRESCENTA BIOSCIENCES

  公开号：WO2022010948A1

  公开（公告）日：2022-01-13

  A class of compounds that bind to FABP4 and inhibit viral replication in cells, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with an additional therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of viral diseases. Formula I

  一类与FABP4结合并抑制细胞中病毒复制的化合物，以及包含该类化合物的药物组合物，与药学上可接受的稀释剂或载体结合，可选地，与另一种治疗活性剂结合，以及这些化合物在医学上的使用和用于制备治疗病毒性疾病的药物的公式I。
• A convenient synthesis of quinolines by reactions of o-isocyano-β-methoxystyrenes with nucleophiles
  作者：Kazuhiro Kobayashi、Keiichi Yoneda、Kazuna Miyamoto、Osamu Morikawa、Hisatoshi Konishi

  DOI：10.1016/j.tet.2004.09.069

  日期：2004.12

  2,4-Disubstituted quinolines have been synthesized by reactions of o-isocyano-beta-methoxystyrenes, which can be easily prepared from commercially available o-aminophenyl ketones in three steps, with alkyl(or aryl)lithiums in generally good yields. Subsequently, oisocyano-beta-methoxystyrenes have also proved to react efficiently with lithium dialkylamides to afford the corresponding 4-substituted N,Ndialkylquinolin-2-amines in satisfactory yields. (C) 2004 Elsevier Ltd. All rights reserved.