7-allyl-6-oxaspiro[4.5]dec-8-en-10-one | 1314303-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 7-allyl-6-oxaspiro[4.5]dec-8-en-10-one
• 英文别名: 7-Prop-2-enyl-6-oxaspiro[4.5]dec-8-en-10-one
• CAS: 1314303-33-7
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: WNXQGUKCCOPKID-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-allyl-6-oxaspiro[4.5]dec-8-en-10-one 在 (triphenylphosphine)copper(I) hydride hexamer 作用下， 以 乙醇 、 水 、 苯 为溶剂， 反应 18.5h， 生成
  参考文献：
  名称：

  Divergent approach to the polymaxenolide and pinnaic acid cores

  摘要：

  The divergent syntheses of the spirocyclic pyran core of polymaxenolide and the spirocyclic piperidine core of pinnaic acid have been achieved. Our divergent approach takes advantage of highly efficient Achmatowicz and aza-Achmatowicz rearrangements to generate the highly functionalised cores, which are then regioselectively modified. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.047
• 作为产物：
  描述：

  (+/-)-2-(1'-hydroxy-cyclopentyl)-furane 在 三氟化硼乙醚 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 、 氯仿 为溶剂， 反应 1.0h， 生成 7-allyl-6-oxaspiro[4.5]dec-8-en-10-one
  参考文献：
  名称：

  Divergent approach to the polymaxenolide and pinnaic acid cores

  摘要：

  The divergent syntheses of the spirocyclic pyran core of polymaxenolide and the spirocyclic piperidine core of pinnaic acid have been achieved. Our divergent approach takes advantage of highly efficient Achmatowicz and aza-Achmatowicz rearrangements to generate the highly functionalised cores, which are then regioselectively modified. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.04.047

文献信息

• Divergent approach to the polymaxenolide and pinnaic acid cores
  作者：Frank D. Ferrari、Andrew J. Ledgard、Rodolfo Marquez

  DOI：10.1016/j.tet.2011.04.047

  日期：2011.7

  The divergent syntheses of the spirocyclic pyran core of polymaxenolide and the spirocyclic piperidine core of pinnaic acid have been achieved. Our divergent approach takes advantage of highly efficient Achmatowicz and aza-Achmatowicz rearrangements to generate the highly functionalised cores, which are then regioselectively modified. (C) 2011 Elsevier Ltd. All rights reserved.