5-acetyl-1-(4-fluorobenzyl)tetrazole | 1355359-01-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-acetyl-1-(4-fluorobenzyl)tetrazole
• CAS: 1355359-01-1
• 化学式: C₁₀H₉FN₄O
• 分子量: 220.206
• InChiKey: KKOCDWJVKUDRLO-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5-acetyl-1-(4-fluorobenzyl)tetrazole 、 在 lithium hexamethyldisilazane 、 盐酸 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 2.0h， 以44%的产率得到
  参考文献：
  名称：

  Thymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles

  摘要：

  N3 of thymidine and of 3'-azido-3'-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.11.079