6-chloro-2-(2-((3R,4R)-4-methyl-1-phenylhex-5-en-3-yl)hydrazinyl)quinoline | 1207873-43-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-chloro-2-(2-((3R,4R)-4-methyl-1-phenylhex-5-en-3-yl)hydrazinyl)quinoline
• 英文别名: 1-(6-chloroquinolin-2-yl)-2-[(3R,4R)-4-methyl-1-phenylhex-5-en-3-yl]hydrazine
• CAS: 1207873-43-5
• 化学式: C₂₂H₂₄ClN₃
• 分子量: 365.906
• InChiKey: BMFAKJXYCDZIOQ-OXQOHEQNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-chloro-2-(2-((3R,4R)-4-methyl-1-phenylhex-5-en-3-yl)hydrazinyl)quinoline 在 甲醇 、 samarium diiodide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Asymmetric Allylation, Crotylation, and Cinnamylation of N-Heteroaryl Hydrazones

  摘要：

  A new class of N-heteroaryl hydrazones has been developed as an alternative to N-acylhydrazones and 2-aminophenol-derived imines in asymmetric allylation, crotylation, and cinnamylation reactions with chiral allylchlorosilanes. The hydrazones are readily and inexpensively prepared, perform well in the allylation chemistry, and more importantly, the product hydrazides may be smoothly reduced by Pd(OH)(2)-catalyzed hydrogenation to reveal the corresponding amine products.

  DOI：

  10.1021/ol9026864
• 作为产物：
  描述：

  (4R,5R)-2-but-2-enyl-2-chloro-3,4-dimethyl-5-phenyl-1,3,2-oxazasilolidine 、 6-chloro-N-(3-phenylpropylideneamino)quinolin-2-amine 以 二氯甲烷 为溶剂， 反应 24.0h， 以67%的产率得到6-chloro-2-(2-((3R,4R)-4-methyl-1-phenylhex-5-en-3-yl)hydrazinyl)quinoline
  参考文献：
  名称：

  Asymmetric Allylation, Crotylation, and Cinnamylation of N-Heteroaryl Hydrazones

  摘要：

  A new class of N-heteroaryl hydrazones has been developed as an alternative to N-acylhydrazones and 2-aminophenol-derived imines in asymmetric allylation, crotylation, and cinnamylation reactions with chiral allylchlorosilanes. The hydrazones are readily and inexpensively prepared, perform well in the allylation chemistry, and more importantly, the product hydrazides may be smoothly reduced by Pd(OH)(2)-catalyzed hydrogenation to reveal the corresponding amine products.

  DOI：

  10.1021/ol9026864