2,2-bis(hexyloxy)propan-1-ol | 1197878-92-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bis(hexyloxy)propan-1-ol
• 英文别名: 2,2-dihexoxypropan-1-ol
• CAS: 1197878-92-4
• 化学式: C₁₅H₃₂O₃
• 分子量: 260.417
• InChiKey: JVRJIULHMJJECO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,2-bis(hexyloxy)propan-1-ol 在 吡啶 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成 sodium 3-((2,2-bis(hexyloxy)propoxy)carbonyl)propane-1-sulfonate
  参考文献：
  名称：

  WO2021026316A5

  摘要：

  公开号：

  WO2021026316A5
• 作为产物：
  描述：

  正己醇 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 49.0h， 生成 2,2-bis(hexyloxy)propan-1-ol
  参考文献：
  名称：

  WO2021026316A5

  摘要：

  公开号：

  WO2021026316A5

文献信息

• Anionic acid-labile surfactants and methods of use
  申请人：Powell Matthew Jacob

  公开号：US20090292136A1

  公开（公告）日：2009-11-26

  Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R 1 is independently selected from —(CH 2 ) 0-9 CH 3 , R 2 is selected from the group consisting of —H and —(CH 2 ) 0-5 CH 3 , Y is an anion, X is a cation, and n is an integer from 1 to 8.

  阴离子酸敏感表面活性剂通常包括由以下公式表示的化合物：其中R1独立地选自—(CH2)0-9CH3，R2选自—H和—( )0-5CH3，Y是阴离子，X是阳离子，n是1到8之间的整数。
• NON-IONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
  申请人：Powell Matthew Jacob

  公开号：US20120309954A1

  公开（公告）日：2012-12-06

  A compound may generally comprise the formula: wherein R 1 is independently selected from C 2 -C 10 alkyl or substituted alkyl, R 2 is independently selected from the group consisting of —H and C 1 -C 6 alkyl or substituted alkyl, X is selected from the group consisting of —NH— and —O—, Y is a carbohydrate, and m is an integer from 1 to 8. The compound may comprise a non-ionic acid labile surfactant. The compound may be used to facilitate solubilization of proteins and other molecules in an aqueous environment.

  一个化合物通常包括以下公式：其中R1独立地选自C2-C10烷基或取代烷基，R2独立地选自—H和C1-C6烷基或取代烷基的群，X选自—NH—和—O—的群，Y是一种碳水化合物，m是1到8的整数。该化合物可能包括非离子酸敏感表面活性剂。该化合物可用于促进蛋白质和其他分子在水环境中的溶解。
• ANIONIC ACID-LABILE SURFACTANTS AND METHODS OF USE
  申请人：Powell Matthew Jacob

  公开号：US20110282096A1

  公开（公告）日：2011-11-17

  Anionic acid-labile surfactants may generally comprise compounds represented by the formula: wherein R 1 is independently selected from —(CH 2 ) 0-9 CH 3 , R 2 is selected from the group consisting of —H and —(CH 2 ) 0-5 CH 3 , Y is an anion, X is a cation, and n is an integer from 1 to 8. Methods of making and using the anionic acid-labile surfactants are also described. The anionic acid-labile surfactants may be used to facilitate the solubilisation of proteins and other molecules in an aqueous environment.

  阴离子酸敏感表面活性剂通常包括以下化合物：其中R1独立地选自—（CH2）0-9CH3，R2选自—H和—（ ）0-5CH3的群，Y是一个阴离子，X是一个阳离子，n是1到8的整数。还描述了制备和使用阴离子酸敏感表面活性剂的方法。阴离子酸敏感表面活性剂可用于促进蛋白质和其他分子在水性环境中的溶解。
• A General Approach to Anionic Acid-Labile Surfactants with Tunable Properties
  作者：Miaosheng Li、Matthew J. Powell、Trust T. Razunguzwa、George A. O’Doherty

  DOI：10.1021/jo100954q

  日期：2010.9.17

  A general approach to the synthesis of a new series of unique sulfate anionic acid-labile surfactants (AALS) was developed. In this approach, the ketal was derived from methyl pyruvate, and the sulfate motif was introduced via sulfitylation of the alcohol, oxidation, and finally conversion of the sulfate diester to the desired sodium salt. The physicochemical properties in aqueous solution of this novel series of surfactants, such as CMCs, solubility, acid lability, and stability were studied.
• ACID-LABILE SURFACTANTS
  申请人：Promega Corporation

  公开号：EP4010327A1

  公开（公告）日：2022-06-15