4-[(7-氯-3-甲基喹啉-4-基)氨基]-2-(二乙基氨基甲基)苯酚 | 5429-78-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 4-[(7-氯-3-甲基喹啉-4-基)氨基]-2-(二乙基氨基甲基)苯酚
• 英文名称: 4-(7-chloro-3-methyl-[4]quinolylamino)-2-diethylaminomethyl-phenol
• 英文别名: 4-(7-Chlor-3-methyl-[4]chinolylamino)-2-diaethylaminomethyl-phenol；4-((7-Chloro-3-methylquinolin-4-yl)amino)-2-((diethylamino)methyl)phenol, dihydrochloride；4-[(7-chloro-3-methylquinolin-4-yl)amino]-2-(diethylaminomethyl)phenol
• CAS: 5429-78-7
• 化学式: C₂₁H₂₄ClN₃O
• 分子量: 369.894
• InChiKey: MZPCIZJSUQXXIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  48.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-乙酰胺-2-二乙氨甲基苯酚 在 盐酸 作用下， 生成 4-[(7-氯-3-甲基喹啉-4-基)氨基]-2-(二乙基氨基甲基)苯酚
  参考文献：
  名称：

  氨基烷基酚作为抗疟药（杂环氨基）-α-氨基-邻甲酚；迷彩的合成。

  摘要：

  DOI：

  10.1021/ja01184a023

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING AMODIAQUINE AND ANTI-DIABETES DRUG AS EFFECTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF DIABETES
  申请人：Novmetapharma Co., Ltd.

  公开号：EP3498279A1

  公开（公告）日：2019-06-19

  The present invention relates to a pharmaceutical composition for preventing or treating diabetes, and controlling a side effect from peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation, wherein the pharmaceutical composition comprises (a) an amodiaquine compound or a pharmaceutically acceptable salt thereof and (b) an antidiabetic drug as active ingredients. Specifically, the composition prevents or treats simultaneously one or more selected from the group consisting of type 2 diabetes reactive to PPAR-gamma activation, and obesity, dyslipidemia, cardiovascular diseases, and fatty cirrhosis reactive to peroxisome proliferator-activated receptor-alpha (PPAR- alpha) activation.

  本发明涉及一种用于预防或治疗糖尿病以及控制过氧化物酶体增殖物激活受体-γ（PPAR-γ）激活产生的副作用的药物组合物，其中药物组合物包括(a)作为活性成分的阿莫地喹化合物或其药学上可接受的盐和(b)抗糖尿病药物。具体地说，该组合物可同时预防或治疗选自以下组别的一种或多种疾病：对 PPAR-gamma 激活有反应的 2 型糖尿病，以及对过氧化物酶体增殖激活受体-α（PPAR-α）激活有反应的肥胖症、血脂异常、心血管疾病和脂肪性肝硬化。
• TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF
  申请人：Nagarajan Kuppuswamy

  公开号：US20170165254A1

  公开（公告）日：2017-06-15

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.
• [EN] TREATING FLAVIVIRUS INFECTIONS WITH AMODIAQUINE AND DERIVATIVES THEREOF<br/>[FR] TRAITEMENT D'INFECTIONS PAR UN FLAVIVIRUS AVEC DE L'AMODIAQUINE ET SES DÉRIVÉS
  申请人：UNIV GEORGETOWN

  公开号：WO2015120127A2

  公开（公告）日：2015-08-13

  Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a Flavivirus inhibitor. These methods are useful in treating, preventing, and/or ameliorating Flavivirus infections such as, for example, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus.