N-[2-(pyridin-2-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-4-hydroxy-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide | 1274918-49-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-[2-(pyridin-2-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]-4-hydroxy-1-isopropyl-2-oxo-1,2-dihydroquinoline-3-carboxamide
• 英文别名: 4-hydroxy-2-oxo-1-propan-2-yl-N-[2-(pyridin-2-ylmethyl)-1-azabicyclo[2.2.2]octan-3-yl]quinoline-3-carboxamide
• CAS: 1274918-49-8
• 化学式: C₂₆H₃₀N₄O₃
• 分子量: 446.549
• InChiKey: VIQGYUPBLHQXTR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  33
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  85.8
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS A 5-HT4 RECEPTOR LIGANDS<br/>[FR] COMPOSÉS DE 1,2-DIHYDRO-2-OXOQUINOLÉINE COMME LIGANDS DES RÉCEPTEURS 5-HT4
  申请人：SUVEN LIFE SCIENCES LTD

  公开号：WO2011030349A1

  公开（公告）日：2011-03-17

  The present invention relates to novel l,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. Formula (I) The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.

  本发明涉及新型l,2-二氢-2-氧喹啉化合物的公式(I)，以及它们的衍生物、前药、互变异构体、立体异构体、多晶形态、溶剂合物、水合物、代谢物、N-氧化物、药学上可接受的盐和含有它们的组合物。公式(I) 本发明还涉及上述新型化合物及其衍生物、前药、互变异构体、立体异构体、多晶形态、溶剂合物、水合物、代谢物、N-氧化物、药学上可接受的盐和含有它们的组合物的制备方法。本发明的化合物在治疗/预防由5-HT4受体活性介导的各种疾病中具有用途。
• L -DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
  申请人：Suven Life Sciences Limited

  公开号：EP2507225B1

  公开（公告）日：2016-06-01
• 1,2-DIHYDRO-2-OXOQUINOLINE COMPOUNDS AS 5-HT4 RECEPTOR LIGANDS
  申请人：Nirogi Ramakrishna

  公开号：US20120277216A1

  公开（公告）日：2012-11-01

  The present invention relates to novel 1,2-dihydro-2-oxoquinoline compounds of the formula (I), and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their derivatives, prodrugs, tautomers, stereoisomers, polymorphs, solvates, hydrates, metabolites, N-oxides, pharmaceutically acceptable salts and compositions containing them. The compounds of the present invention are useful in the treatment/prevention of various disorders that are mediated by 5-HT4 receptor activity.
• US8598204B2
  申请人：——

  公开号：US8598204B2

  公开（公告）日：2013-12-03