2-(5-guanidino-1H-benzoimidazol-2-ylmethyl)-3-methyl-N-[2-(2,6-dimethoxy)phenoxyethyl]-3H-benzoimidazole-5-carboxamide | 214780-67-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-guanidino-1H-benzoimidazol-2-ylmethyl)-3-methyl-N-[2-(2,6-dimethoxy)phenoxyethyl]-3H-benzoimidazole-5-carboxamide
• 英文别名: 2-[[6-(diaminomethylideneamino)-1H-benzimidazol-2-yl]methyl]-N-[2-(2,6-dimethoxyphenoxy)ethyl]-3-methylbenzimidazole-5-carboxamide
• CAS: 214780-67-3
• 化学式: C₂₈H₃₀N₈O₄
• 分子量: 542.597
• InChiKey: JPCVWNFQKIEZFM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  40
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  168
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Novel compounds and compositions for treating diseases asociated with protease activity
  申请人：——

  公开号：US20010053779A1

  公开（公告）日：2001-12-20

  Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

  描述了用于预防和治疗由肥大细胞介导的炎症性疾病的新化合物、组合物和方法。这些化合物、组合物和方法对预防和治疗与呼吸道相关的炎症性疾病（如哮喘和过敏性鼻炎）以及其他类型的免疫介导性炎症性疾病（如类风湿关节炎、结膜炎和炎症性肠病、各种皮肤病症以及某些病毒性疾病）有效。这些化合物包括对肥大细胞蛋白酶组胺酶的有效和选择性抑制剂。用于治疗这些疾病的组合物包括口服、吸入、局部和静脉制剂，以及包含这些制剂的装置。
• Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
  申请人：Axys Pharmaceuticals, Inc.

  公开号：US20030212120A1

  公开（公告）日：2003-11-13

  Novel compounds, compositions and methods effective for the prevention and treatment of mast-cell mediated inflammatory disorders are described. The compounds, compositions and methods are effective for the prevention and treatment of inflammatory diseases associated with the respiratory tract, such as asthma and allergic rhinitis, as well as other types of immunomediated inflammatory disorders, such as rheumatoid arthritis, conjunctivitis and inflammatory bowel disease, various dermatological conditions, as well as certain viral conditions. The compounds comprise potent and selective inhibitors of the mast cell protease tryptase. The compositions for treating these conditions include oral, inhalant, topical and parenteral preparations as well as devices comprising such preparations.

  本发明描述了一种新型化合物、组合物和方法，用于预防和治疗由肥大细胞介导的炎症性疾病。这些化合物、组合物和方法对预防和治疗呼吸道相关的炎症性疾病，如哮喘和过敏性鼻炎，以及其他类型的免疫介导的炎症性疾病，如类风湿性关节炎、结膜炎和炎症性肠病、各种皮肤病和某些病毒性疾病均有效。这些化合物包括强效和选择性的肥大细胞蛋白酶酶抑制剂。治疗这些疾病的组合物包括口服、吸入、局部和静脉制剂，以及包含这些制剂的装置。
• US6562854B2
  申请人：——

  公开号：US6562854B2

  公开（公告）日：2003-05-13