1-{2-[3-(3-pyridyl)propoxy]ethyl}-1H-imidazo[4,5-c]quinolin-4-amine | 436157-88-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-{2-[3-(3-pyridyl)propoxy]ethyl}-1H-imidazo[4,5-c]quinolin-4-amine
• 英文别名: 1-{2-[3-(pyridin-3-yl)propoxy]ethyl}-1H-imidazo[4,5-c]quinolin-4-amine；1-[2-(3-Pyridin-3-ylpropoxy)ethyl]imidazo[4,5-c]quinolin-4-amine
• CAS: 436157-88-9
• 化学式: C₂₀H₂₁N₅O
• 分子量: 347.42
• InChiKey: DYJVCYHSCVKKFB-UHFFFAOYSA-N

物化性质

• 沸点：
  614.5±65.0 °C(Predicted)
• 密度：
  1.29±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  78.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Pharmaceutical formulation comprising an immune response modifier
  申请人：3M Innovative Properties Company

  公开号：US20030199538A1

  公开（公告）日：2003-10-23

  Pharmaceutical formulations comprising an immune response modifier (IRM) chosen from imidazoquinoline amines, imidazotetrahydroquinoline amines, imidazopyridine amines, 6,7-fused cycloalkylimidazopyridine amines, 1,2-bridged imidazoquinoline amines, thiazolo-quinolineamines, oxazolo-quinolinamines, thiazolo-pyridinamines, oxazolo-pyridinamines, imidazonaphthyridine amines, tetrahydroimidazonaphthyridine amines, and thiazolonaphthyridine amines; a fatty acid; and a hydrophobic, aprotic component miscible with the fatty acid are useful for the treatment of dermal associated conditions. Novel topical formulations are provided. In one embodiment, the topical formulations are advantageous for treatment of actinic keratosis, postsurgical scars, basal cell carcinoma, atopic dermatitis, and warts.

  含有免疫应答调节剂（IRM）的制药配方，所述IRM选择自咪唑喹啉胺，咪唑四氢喹啉胺，咪唑吡啶胺，6,7-融合环烷基咪唑吡啶胺，1,2-桥联咪唑喹啉胺，噻唑喹啉胺，噁唑喹啉胺，噻唑吡啶胺，噁唑吡啶胺，咪唑萘啶胺，四氢咪唑萘啶胺和噻唑萘啶胺；脂肪酸；和与脂肪酸混溶的疏水性无极性成分，对治疗皮肤相关疾病有用。提供了新型局部制剂。在一种实施方式中，该局部制剂对于治疗光化性角化症，手术后疤痕，基底细胞癌，特应性皮炎和疣等方面具有优势。
• Heterocyclic ether substituted imidazoquinolines
  申请人：3M Innovative Properties Company

  公开号：US20040072858A1

  公开（公告）日：2004-04-15

  Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain ether and heterocyclyl or heteroaryl functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

  在1位点含有醚和杂环基或杂环芳基的咪唑喹啉和四氢咪唑喹啉化合物可作为免疫反应调节剂。本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并可用于治疗包括病毒性疾病和肿瘤性疾病在内的多种疾病。
• Methods and compositions related to IRM compounds and toll-like recptor pathways
  申请人：3M Innovative Properties Company

  公开号：US20040014779A1

  公开（公告）日：2004-01-22

  Methods for identifying a compound that activates a TLR-mediated cellular signaling pathway is disclosed. The method includes (a) exposing a TLR-positive cell culture to a test compound and measuring a TLR-mediated cellular response; (b) exposing a TLR-negative cell culture to a test compound and measuring a TLR-mediated cellular response; and (c) identifying the test compound as an IRM if the cellular response in the TLR-positive cell culture is greater than the cellular response of the TLR-negative cell culture. Methods of eliciting a TLR-mediated cellular response are also disclosed. Such methods include administration of an IRM compound to an IRM-responsive cell so that the IRM compounds affects at least one TLR-mediate cellular signaling pathway.

  公开了一种识别激活TLR介导的细胞信号通路的化合物的方法。该方法包括：（a）将TLR阳性细胞培养物暴露于测试化合物中，并测量TLR介导的细胞反应；（b）将TLR阴性细胞培养物暴露于测试化合物中，并测量TLR介导的细胞反应；以及（c）如果TLR阳性细胞培养物中的细胞反应大于TLR阴性细胞培养物的细胞反应，则将测试化合物识别为IRM。还公开了一种诱导TLR介导的细胞反应的方法。这些方法包括将IRM化合物给IRM反应细胞，以便IRM化合物影响至少一个TLR介导的细胞信号通路。
• N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide, a pharmaceutical composition comprising the same and use thereof
  申请人：3M Innovative Properties Company

  公开号：EP1719511A2

  公开（公告）日：2006-11-08

  N-[4-(4-amino-2-ethyl-1H-imidazo[4,5-c]quinolin-1-yl)butyl]methanesulfonamide, a pharmaceutical composition comprising the same and use thereof.

  N-[4-(4-氨基-2-乙基-1H-咪唑并[4,5-c]喹啉-1-基)丁基]甲磺酰胺、由其组成的药物组合物及其用途。
• Prophylactic treatment of UV-induced epidermal neoplasia
  申请人：3M Innovative Properties Company

  公开号：US20040175336A1

  公开（公告）日：2004-09-09

  The present invention provides a method of protecting a subject against UV-induced epidermal neoplasia. Generally, the method includes administering to a subject an IRM compound in an amount effective to provide protection against UV-induced epidermal neoplasia. The present invention also provides compositions that include an IRM compound in an amount effective for providing protection against UV-induced epidermal neoplasia.

  本发明提供了一种保护受试者免受紫外线诱发的表皮瘤病的方法。一般来说，该方法包括向受试者施用有效量的IRM化合物，以提供对紫外线诱导的表皮瘤的保护。本发明还提供了包括IRM化合物的组合物，其有效量可提供对紫外线诱导的表皮瘤的保护。