[2-(3-chloro-8-methoxy-indolo[3,2-c]quinolin-11-yl)-ethyl]-dimethyl-amine | 65287-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [2-(3-chloro-8-methoxy-indolo[3,2-c]quinolin-11-yl)-ethyl]-dimethyl-amine
• 英文别名: 3-Chloro-8-methoxy-N,N-dimethyl-11H-indolo[3,2-c]quinolin-11-ethanamine；2-(3-chloro-8-methoxyindolo[3,2-c]quinolin-11-yl)-N,N-dimethylethanamine
• CAS: 65287-63-0
• 化学式: C₂₀H₂₀ClN₃O
• 分子量: 353.851
• InChiKey: FQOANHTZEFHNSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  methyl N-(3-chlorophenyl)-β-alaninate 在 吡啶 、 盐酸 、 sodium hydroxide 、 三氯化铝 、 五氯化磷 、 苄基三乙基氯化铵 、 溶剂黄146 作用下， 以 1,4-二氧六环 、 异丙醇 、 甲苯 为溶剂， 反应 32.83h， 生成 [2-(3-chloro-8-methoxy-indolo[3,2-c]quinolin-11-yl)-ethyl]-dimethyl-amine
  参考文献：
  名称：

  Structure-activity relationships of antimalarial indolo[3,2-c]quinolines [1, 2]

  摘要：

  Structure-activity relationships have been ascertained and chemical methodology developed for a series of antimalarial 3-chloroindolo[3,2-c]quinoline-5-oxides. The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3. Substitution at positions 7, 8, 9, 10 is not essential, although the most potent analog in our studies was the 8-nitro compound 4vv.

  DOI：

  10.1016/0223-5234(93)90036-e

文献信息

• Structure-activity relationships of antimalarial indolo[3,2-c]quinolines [1, 2]
  作者：LM Werbel、SJ Kesten、WR Turner

  DOI：10.1016/0223-5234(93)90036-e

  日期：1993.1

  Structure-activity relationships have been ascertained and chemical methodology developed for a series of antimalarial 3-chloroindolo[3,2-c]quinoline-5-oxides. The basic side chain as well as the ring N-oxide are critical for antimalarial activity as is a bromine or chlorine in position 3. Substitution at positions 7, 8, 9, 10 is not essential, although the most potent analog in our studies was the 8-nitro compound 4vv.