N-methyl-2-(4-methoxyphenyl)quinolin-4-amine | 1099705-59-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-methyl-2-(4-methoxyphenyl)quinolin-4-amine
• 英文别名: 2-(4-methoxyphenyl)-N-methylquinolin-4-amine
• CAS: 1099705-59-5
• 化学式: C₁₇H₁₆N₂O
• 分子量: 264.327
• InChiKey: MNVXJMHOBNDWOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.95
• 重原子数：
  20.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  34.15
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  N-甲基甲酰胺 、 4-chloro-2-(4-methoxyphenyl)quinoline 以23%的产率得到N-methyl-2-(4-methoxyphenyl)quinolin-4-amine
  参考文献：
  名称：

  Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents

  摘要：

  Novel 4-amino-2-phenylquinoline derivatives were synthesized by reacting various 4-chloro-2-aryl-quinoline compounds having activated chloro group with the corresponding imide solvents at reflux for overnight. The activity of amination by the amide solvents depended on the competition between the steric and electronic effect of the N-substituents on the amino group. Their activities were shown as N,N-dimethylformamide>N,N-diethylformamide>N-methylformamide>formamide>N,N-dimethylacetamide> N,N-dimethylpropionamide. The yields for the amination products seemed proportional to the ease of the dissociation of the amides. (C) 2008 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tet.2008.09.100

文献信息

• [EN] MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS<br/>[FR] MOLÉCULES QUI SE LIENT À TDP-43 POUR LE TRAITEMENT DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE ET DE TROUBLES APPARENTÉS
  申请人：BIOHAVEN THERAPEUTICS LTD

  公开号：WO2021035101A1

  公开（公告）日：2021-02-25

  Pharmaceutical compositions of the invention comprise TDP-43 binding agents having a disease-modifying action in the treatment of diseases associated with TDP-43 that include ALS, FTLD, CTE, hippocampal sclerosis of aging (CARTS), Alzheimers disease, and Alzheimers disease related disorder, and disease that involve excess amounts of TDP-43 in the cytosol.