methyl-3-O-acetyl-2(S),3-dihydroxy-2-methylpropanoate | 144027-61-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl-3-O-acetyl-2(S),3-dihydroxy-2-methylpropanoate
• 英文别名: methyl (2S)-3-acetyloxy-2-hydroxy-2-methylpropanoate
• CAS: 144027-61-2
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: LMRWOXSXMHVQLP-ZETCQYMHSA-N

物化性质

• 沸点：
  217.3±20.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙酸酐 、 甲基2,3-二羟基-2-甲基丙酸酯 在 吡啶 作用下， 以89%的产率得到methyl-3-O-acetyl-2(S),3-dihydroxy-2-methylpropanoate
  参考文献：
  名称：

  Preparation of 2(R) and 2(S) methyl-2-methylglycerates

  摘要：

  Optically pure samples of both enantiomers of methyl 2,3-dihydroxy-2-methylpropanoate were prepared by a chromatographic separation of their (-)-menthyl esters followed by hydrolysis and methylation. Their absolute stereochemistries were established by conversion into their 3-0-acetyl derivatives, compounds of established configuration. NMR and CG-MS methods of determining the optical purities of the diols are described.

  DOI：

  10.1016/s0957-4166(00)86020-6

文献信息

• Asymmetric synthesis of 2-alkyl-2,3-dihydroxypropionates from glycerol
  作者：Kuang-Fu Yen、Biing-Jiun Uang

  DOI：10.1016/s0957-4166(00)80504-2

  日期：1992.6

  The preparation of optically active 2-substituted 2,3-dihydroxypropionates from glycerol is described.