2-(2-azidopropyl)-2-methyl-1,3-dioxolane | 1322805-37-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2-azidopropyl)-2-methyl-1,3-dioxolane
• CAS: 1322805-37-7
• 化学式: C₇H₁₃N₃O₂
• 分子量: 171.199
• InChiKey: WXFLCFPROSBIQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  12.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  67.22
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-(2-azidopropyl)-2-methyl-1,3-dioxolane 在 5 wt% Pd/C 、 氢气 作用下， 以 甲醇 、 乙醚 为溶剂， 以84%的产率得到1-(2-methyl-1,3-dioxolan-2-yl)propan-2-amine
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w
• 作为产物：
  描述：

  3-戊烯-2-酮 、 乙二醇 在 三甲基氯硅烷 、 sodium azide 作用下， 以 二氯甲烷 为溶剂， 反应 8.25h， 以71%的产率得到2-(2-azidopropyl)-2-methyl-1,3-dioxolane
  参考文献：
  名称：

  Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Catalyzed by CAL-B at 38–40 °C

  摘要：

  The (R)-selective chemoenzymatic dynamic kinetic resolution of primary amines was performed at 38-40 degrees C in MTBE, in good to high yields and with high enantiomeric excesses. These reactions associating CAL-B to octanethiol as radical racemizing agent were carried out in the presence of methyl beta-methoxy propanoate as acyl donor, under photochemical irradiation at 350 nm in glassware.

  DOI：

  10.1021/jo201256w