2'-benzimidazolyl 6-acetamido-6-deoxy-1-thio-β-D-galactofuranoside | 1240496-85-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'-benzimidazolyl 6-acetamido-6-deoxy-1-thio-β-D-galactofuranoside
• CAS: 1240496-85-8
• 化学式: C₁₅H₁₉N₃O₅S
• 分子量: 353.399
• InChiKey: YZHIIZMISJIROO-POQQGIQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  24.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  127.7
• 氢给体数：
  5.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2'-benzimidazolyl 6-acetamido-6-deoxy-1-thio-β-D-galactofuranoside 、 disodium UDP 在 Amberlite IR-120 H+ 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania

  摘要：

  The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.02.020
• 作为产物：
  描述：

  2'-benzimidazolyl 6-acetamido-5-O-acetyl-2,3-di-O-benzoyl-6-deoxy-1-thio-β-D-galactofuranoside 在 sodium methylate 作用下， 以 甲醇 为溶剂， 以90%的产率得到2'-benzimidazolyl 6-acetamido-6-deoxy-1-thio-β-D-galactofuranoside
  参考文献：
  名称：

  Synthetic UDP-furanoses inhibit the growth of the parasite Leishmania

  摘要：

  The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2010.02.020