2-((5-chloropyridin-2-yl)oxy)acetic acid | 79674-59-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-((5-chloropyridin-2-yl)oxy)acetic acid
• 英文别名: Acetic acid, 2-[(5-chloro-2-pyridinyl)oxy]-；2-(5-chloropyridin-2-yl)oxyacetic acid
• CAS: 79674-59-2
• 化学式: C₇H₆ClNO₃
• 分子量: 187.583
• InChiKey: RRKHLHRDNNAYJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-((5-chloropyridin-2-yl)oxy)acetic acid 、 (R)-N-(3-aminobicyclo[1.1.1]pentan-1-yl)-6-chloro-4-oxochroman-2-carboxamide trifluoroacetic acid 在 三乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 (2R)-6-chloro-N-(3-{2-[(5-chloropyridin-2-yl)oxy]acetamido}bicyclo[1.1.1]pentan-1-yl)-4-oxo-3,4-dihydro-2H-1-benzopyran-2-carboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED CYCLOLAKYLS AS MODULATORS OF THE INTEGRATED STRESS PATHWAY
  [FR] CYCLOLALKYLES SUBSTITUÉS EN TANT QUE MODULATEURS DE LA VOIE DE STRESS INTÉGRÉE

  摘要：

  本文提供了用于调节综合应激反应（ISR）并治疗相关疾病、疾病和症状的化合物、组合物和方法。

  公开号：

  WO2020223536A1
• 作为产物：
  描述：

  5-氯-2-羟基吡啶 在 lithium hydroxide monohydrate 、 silver carbonate 作用下， 以 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 2-((5-chloropyridin-2-yl)oxy)acetic acid
  参考文献：
  名称：

  [EN] CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS
  [FR] COMPOSÉS CHIMIQUES UTILISÉS COMME INHIBITEURS DE LA VOIE ATF4

  摘要：

  这项发明涉及取代的桥环脂环烷衍生物。具体而言，该发明涉及符合以下式（IIIQ）的化合物：其中X6'，a，b，C8'，D8'，L82'，L83'，R81'，R82'，R83'，R84'，R85'，R86'，z82'，z84'，z85'和z86'如本文所定义；或其盐。该发明的化合物是ATF4途径的抑制剂。因此，该发明进一步涉及包括该发明化合物的药物组合物。该发明还进一步涉及使用该发明化合物或包括该发明化合物的药物组合物抑制ATF4途径和治疗相关疾病的方法。

  公开号：

  WO2018225093A1

文献信息

• [EN] CHEMICAL COMPOUNDS AS ATF4 PATHWAY INHIBITORS<br/>[FR] COMPOSÉS CHIMIQUES UTILISÉS COMME INHIBITEURS DE LA VOIE ATF4
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2018225093A1

  公开（公告）日：2018-12-13

  The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (IIIQ): wherein X6', a, b, C8', D8', L82', L83', R81', R82', R83', R84', R85', R86', z82', z84', z85', and z86' are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

  这项发明涉及取代的桥环脂环烷衍生物。具体而言，该发明涉及符合以下式（IIIQ）的化合物：其中X6'，a，b，C8'，D8'，L82'，L83'，R81'，R82'，R83'，R84'，R85'，R86'，z82'，z84'，z85'和z86'如本文所定义；或其盐。该发明的化合物是ATF4途径的抑制剂。因此，该发明进一步涉及包括该发明化合物的药物组合物。该发明还进一步涉及使用该发明化合物或包括该发明化合物的药物组合物抑制ATF4途径和治疗相关疾病的方法。
• HEILMANN, D.;KEMPTER, G., WISS. Z. PAD. HOCHSCH. K. LIEBKNECHT POTSDAM, 1981, 25, N 1, 35-38
  作者：HEILMANN, D.、KEMPTER, G.

  DOI：——

  日期：——
• RESISTANCE TO AUXINIC HERBICIDES
  申请人：Walsh A. Terence

  公开号：US20070220629A1

  公开（公告）日：2007-09-20

  The invention provides methods of identifying herbicidal auxins. The invention further provides auxin-herbicide-resistant plants and genes conferring auxin-herbicide resistance. This invention also provides a method of identifying other proteins that bind picolinate auxins from additional plant species. The invention further provides a method to identify the molecular binding site for picolinate auxins. The invention also includes the use of the picolinate herbicidal auxin target site proteins, and methods of discovering new compounds with herbicidal or plant growth regulatory activity. The invention also includes methods for producing plants that are resistant to picolinate herbicidal auxins. Specific examples of novel proteins associated with herbicide binding include AFB5, AFB4, and SGT1b.
• Chemical Compounds as ATF-4 Pathway Inhibitors
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：US20210093619A1

  公开（公告）日：2021-04-01

  The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula IIIQ: wherein X 6′ , a, b, C 8′ , D 8′ , L 82′ , L 83′ , R 81′ , R 82′ , R 83′ , R 84′ , R 85′ , R 86′ , z 82′ , z 84′ , z 85′ , and z 86′ are as defined herein; or salts thereof. The compounds of the invention are inhibitors of the ATF4 pathway. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
• US7820883B2
  申请人：——

  公开号：US7820883B2

  公开（公告）日：2010-10-26