7α-methyl-19-nor-4-androstenedione | 17000-78-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7α-methyl-19-nor-4-androstenedione
• 英文别名: 7α-methylestr-4-en-3,17-dione；7α-methyl-estr-4-ene-3,17-dione；7alpha-Methylestr-4-ene-3,17-dione；(7R,8R,9S,10R,13S,14S)-7,13-dimethyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-3,17-dione
• CAS: 17000-78-1
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.414
• InChiKey: IHFREKJAIFEZMQ-ARTWWJDJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7α-methyl-19-nor-4-androstenedione 生成 17β-Formyl-7α-Methylestr-4-en-3-one
  参考文献：
  名称：

  17.beta.-Difluoromethyl steroids

  摘要：

  公开了具有孕激素、抗孕激素活性的17-β-二氟甲基类固醇，可用作男性和女性避孕剂。

  公开号：

  US04416822A1
• 作为产物：
  描述：

  3-acetoxy-19-nor-androsta-3,5-dien-17-one 在 N-溴代丁二酰亚胺(NBS) 、 calcium carbonate 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 7α-methyl-19-nor-4-androstenedione
  参考文献：
  名称：

  一种7α-甲基-3,3-二甲氧基-5(10)-雄烯-17-酮的制备方法

  摘要：

  本发明公开了一种合成7α‑甲基‑3,3‑二甲氧基‑5(10)‑雄烯‑17‑酮的新方法。该方法以市场易得的19‑去甲‑4‑雄烯二酮作为原料，依次经过酰化反应、溴化反应、脱溴反应以及甲基化反应后获得中间体7α‑甲基‑19‑去甲‑4‑雄烯二酮；然后再依次经过缩酮反应、水解反应和醚化反应后获得7α‑甲基‑3,3‑二甲氧基‑5(10)‑雄烯‑17‑酮。该方法所述原料易得，合成反应步骤短，生产成本低，且本发明获得的粗产物后期提纯处理简单、产率高，适合工业化生产。

  公开号：

  CN114249789B

文献信息

• 17Alpha fluoroalkyl steroids, method for producing the same and pharmaceutical compositions containing said compounds
  申请人：——

  公开号：US20040024231A1

  公开（公告）日：2004-02-05

  The invention relates to 17&agr; fluoroalkyl steroids of the general formula (I). STEROID (I), wherein R 3 represents a group of the formula CnFmHo, wherein n=1, 2, 3, 4, 5 or 6, m>1 and m+o=2n+1. The invention further relates to methods for producing the same and to compositions that contain said compounds. The inventive composition of the general formula (I) possess androgenic activity. 1

  这项发明涉及一般式(I)的17α氟烷基类固醇。类固醇(I)，其中R3代表一种具有CnFmHo式的基团，其中n=1, 2, 3, 4, 5或6，m>1且m+o=2n+1。该发明还涉及生产这些类固醇的方法以及含有所述化合物的组合物。一般式(I)的这种创新组合物具有雄激素活性。
• Process for making estra-4,9(10)-diene steroids
  申请人：——

  公开号：US20030004333A1

  公开（公告）日：2003-01-02

  A novel process for making estra-4,9(10)-diene-3,17-dione steroids from readily available 19-nor-androst-4-ene-3-one steroids by a straightforward three-step process. Products of this process are important intermediates in the preparation of biologically active substances.

  一种新型工艺，通过简单的三步过程从易得的19-去甲雄烷-4-烯-3-酮类固醇制备出雌甾-4,9（10）-二烯-3,17-二酮类固醇。该过程的产物是制备生物活性物质的重要中间体。
• Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-halogen steroids that can be produced therefrom, their process for production and use as well as pharmaceutical prepartions that contain these compounds, as well as 7-substituted estra-1,3,5(10)-trienses that can be produced therefrom
  申请人：Zorn Ludwig

  公开号：US20050090477A1

  公开（公告）日：2005-04-28

  A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R 7 , R 10 , R 11 , R 13 , R 17 and R 17′ as well as of the grouping U-V-W-X-Y-Z are indicated in the claims.

  本文介绍了一种新的合成方法，用于制造通式为8、10和12的化合物的上游产品。在这种合成中，通式为4-B的化合物是通过微生物反应产生的。在权利要求中指出了R7、R10、R11、R13、R17和R17'的含义，以及U-V-W-X-Y-Z的分组。
• Microbiological process for the production of 7-substituted 11-hydroxy steroids, 7,17-substituted 11-Halogen steroids and uses thereof
  申请人：Bayer Schering Pharma AG

  公开号：US07262023B2

  公开（公告）日：2007-08-28

  A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R7, R10, R11, R13, R17 and R17′ as well as of the grouping U—V—W—X—Y—Z are indicated in the claims

  本文描述了一种合成上游产物以制造通式为8、10和12的化合物的新方法。在这种合成中，通式为4,B的化合物是通过微生物反应产生的。在权利要求中指出了R7、R10、R11、R13、R17和R17′以及U—V—W—X—Y—Z组合的含义。
• Microbiological process for the production of 7-substitued 11-hydroxy steroids, 7,17-substituted 11-halogen steroids, and uses thereof
  申请人：Zorn Lud-wig

  公开号：US20070298456A1

  公开（公告）日：2007-12-27

  A novel method of synthesis for the manufacture of upstream products for the production of compounds with general formulas 8, 10, and 12 is described. In this synthesis, compounds with general formula 4,B are produced in a microbiological reaction. The meanings of R 7 , R 10 , R 11 , R 13 , R 17 and R 17 ′ as well as of the grouping U—V—W—X—Y-Z are indicated in the claims.

  本文介绍了一种合成上游产品的新方法，用于生产通式为8、10和12的化合物。在这种合成中，通过微生物反应产生通式为4,B的化合物。在权利要求中指出了R7、R10、R11、R13、R17和R17′的含义，以及U—V—W—X—Y-Z的分组含义。